所有成纤维细胞都是平等的，但有些成纤维细胞比其他成纤维细胞更平等

IF 29.4 1区医学 Q1 RHEUMATOLOGY

Nature Reviews Rheumatology Pub Date : 2024-03-11 DOI:10.1038/s41584-024-01097-6

Chrissy Bolton, Adam P. Croft

引用次数: 0

摘要

不同形式的关节炎存在关节受累的特征模式。目前的研究表明，滑膜成纤维细胞的表观遗传编程使其对炎症级联反应多样化，从而导致关节炎的解剖学差异及其对治疗的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

All fibroblasts are equal, but some are more equal than others

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All fibroblasts are equal, but some are more equal than others

Characteristic patterns of joint involvement exist in different forms of arthritis. Research now indicates that epigenetic programming of synovial fibroblasts diversifies their response to inflammatory cascades, leading to this anatomical variation in arthritis and its response to treatment.

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来源期刊

Nature Reviews Rheumatology 医学-风湿病学

CiteScore

29.90

自引率

0.90%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.