通过以肠道微生物为导向的饮食干预实现健康老龄化：关注微生物生物标志物和宿主机制。

IF 11.4 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of Advanced Research Pub Date : 2025-02-01 DOI:10.1016/j.jare.2024.03.005

Yue Xiao , Yingxuan Feng , Jianxin Zhao , Wei Chen , Wenwei Lu

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引用次数: 0

摘要

背景：人口老龄化已成为全球公共卫生的首要问题，预防老年相关疾病和延长健康预期寿命尤为重要。肠道微生物群已成为包括衰老在内的各种宿主生理紊乱的新靶点。全面了解衰老过程中肠道微生物群的变化，尤其是百岁老人的肠道微生物群特征，可为我们通过肠道微生物群导向策略实现健康衰老或干预病理衰老提供可能：本综述旨在总结与衰老相关的肠道微生物群的特征，探索衰老的潜在生物标志物，并以肠道屏障和免疫状态为重点，探讨与微生物群相关的宿主衰老机制。通过总结衰老干预方面现有的有效膳食策略，为未来开发针对肠道微生物群的膳食提供了可能性：本综述主要围绕三个关键概念展开：首先，肠道微生物群已成为调节健康状况和寿命的新目标，其变化与年龄密切相关。因此，我们通过比较百岁老人、老年人和年轻人的微生物群差异，从关键属/种和重要代谢物的层面总结了与衰老相关的肠道微生物群特征。其次，探索与衰老相关的微生物群生物标志物，并探讨未来针对衰老相关微生物群生物标志物使用膳食制度/成分促进人类健康寿命的可能性。第三，膳食干预能有效改善与衰老相关的肠道微生物群失衡，如益生菌、益生元和后益生元，但其效果因人而异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms

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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms

Background

Population aging has become a primary global public health issue, and the prevention of age-associated diseases and prolonging healthy life expectancies are of particular importance. Gut microbiota has emerged as a novel target in various host physiological disorders including aging. Comprehensive understanding on changes of gut microbiota during aging, in particular gut microbiota characteristics of centenarians, can provide us possibility to achieving healthy aging or intervene pathological aging through gut microbiota-directed strategies.

Aim of Review

This review aims to summarize the characteristics of the gut microbiota associated with aging, explore potential biomarkers of aging and address microbiota-associated mechanisms of host aging focusing on intestinal barrier and immune status. By summarizing the existing effective dietary strategies in aging interventions, the probability of developing a diet targeting the gut microbiota in future is provided.

Key Scientific Concepts of Review

This review is focused on three key notions: Firstly, gut microbiota has become a new target for regulating health status and lifespan, and its changes are closely related to age. Thus, we summarized aging-associated gut microbiota features at the levels of key genus/species and important metabolites through comparing the microbiota differences among centenarians, elderly people and younger people. Secondly, exploring microbiota biomarkers related to aging and discussing future possibility using dietary regime/components targeted to aging-related microbiota biomarkers promote human healthy lifespan. Thirdly, dietary intervention can effectively improve the imbalance of gut microbiota related to aging, such as probiotics, prebiotics, and postbiotics, but their effects vary among.

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来源期刊

Journal of Advanced Research Multidisciplinary-Multidisciplinary

CiteScore

21.60

自引率

0.90%

发文量

280

审稿时长

12 weeks

期刊介绍： Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.