{"title":"番石榴代谢物的分离、特征和一氧化氮生成抑制活性","authors":"Hieu Ngo, Tuan Anh Hoang Le, Cong Pham","doi":"10.15625/2525-2518/18298","DOIUrl":null,"url":null,"abstract":"Thirteen compounds, including catechin (1), gallocatechin (2), quercetin (3), myricetin (4), kaempferol 3-O-α-ʟ-arabinofuranoside (5), avicularin (6), guaijaverin (7), quercetin-3-O-β-ᴅ-galactopyranoside (8), quercetin-3-O-β-ᴅ-glucopyranoside (9), quercetin-3-O-β-ᴅ-glucuronide (10), casuarinin (11), ursolic acid (12), and 4-methoxy-3,5-dihydroxybenzoic acid (13) were isolated from the leaves of Psidium guajava. The structures of these compounds were elucidated by modern spectroscopic methods (MS, 1H/13C-NMR) and compared with those reported data. Additionally, all isolated compounds were evaluated for their inhibitory effects on NO production. Among them, compounds 3, 8, 10, and 11 showed inhibitory effects on NO production within IC50 values of 19.30 – 42.86 µM. Compound 13 was firstly isolated from Psidium guajava.","PeriodicalId":23553,"journal":{"name":"Vietnam Journal of Science and Technology","volume":"95 10","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ISOLATION, CHARACTERIZATION, AND NITRIC OXIDE PRODUCTION INHIBITORY ACTIVITIES OF THE METABOLITES FROM PSIDIUM GUAJAVA L.\",\"authors\":\"Hieu Ngo, Tuan Anh Hoang Le, Cong Pham\",\"doi\":\"10.15625/2525-2518/18298\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Thirteen compounds, including catechin (1), gallocatechin (2), quercetin (3), myricetin (4), kaempferol 3-O-α-ʟ-arabinofuranoside (5), avicularin (6), guaijaverin (7), quercetin-3-O-β-ᴅ-galactopyranoside (8), quercetin-3-O-β-ᴅ-glucopyranoside (9), quercetin-3-O-β-ᴅ-glucuronide (10), casuarinin (11), ursolic acid (12), and 4-methoxy-3,5-dihydroxybenzoic acid (13) were isolated from the leaves of Psidium guajava. The structures of these compounds were elucidated by modern spectroscopic methods (MS, 1H/13C-NMR) and compared with those reported data. Additionally, all isolated compounds were evaluated for their inhibitory effects on NO production. Among them, compounds 3, 8, 10, and 11 showed inhibitory effects on NO production within IC50 values of 19.30 – 42.86 µM. Compound 13 was firstly isolated from Psidium guajava.\",\"PeriodicalId\":23553,\"journal\":{\"name\":\"Vietnam Journal of Science and Technology\",\"volume\":\"95 10\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vietnam Journal of Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15625/2525-2518/18298\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vietnam Journal of Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15625/2525-2518/18298","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
从番石榴叶中分离出了槲皮素-3-O-β-ᴅ-吡喃葡萄糖苷（9）、槲皮素-3-O-β-ᴅ-葡萄糖醛酸苷（10）、番荔枝素（11）、熊果酸（12）和 4-甲氧基-3,5-二羟基苯甲酸（13）。通过现代光谱方法（质谱、1H/13C-NMR）阐明了这些化合物的结构，并与已报道的数据进行了比较。此外，还评估了所有分离化合物对 NO 生成的抑制作用。其中，化合物 3、8、10 和 11 对 NO 生成具有抑制作用，IC50 值在 19.30 - 42.86 µM 之间。化合物 13 首先是从番石榴中分离出来的。
ISOLATION, CHARACTERIZATION, AND NITRIC OXIDE PRODUCTION INHIBITORY ACTIVITIES OF THE METABOLITES FROM PSIDIUM GUAJAVA L.
Thirteen compounds, including catechin (1), gallocatechin (2), quercetin (3), myricetin (4), kaempferol 3-O-α-ʟ-arabinofuranoside (5), avicularin (6), guaijaverin (7), quercetin-3-O-β-ᴅ-galactopyranoside (8), quercetin-3-O-β-ᴅ-glucopyranoside (9), quercetin-3-O-β-ᴅ-glucuronide (10), casuarinin (11), ursolic acid (12), and 4-methoxy-3,5-dihydroxybenzoic acid (13) were isolated from the leaves of Psidium guajava. The structures of these compounds were elucidated by modern spectroscopic methods (MS, 1H/13C-NMR) and compared with those reported data. Additionally, all isolated compounds were evaluated for their inhibitory effects on NO production. Among them, compounds 3, 8, 10, and 11 showed inhibitory effects on NO production within IC50 values of 19.30 – 42.86 µM. Compound 13 was firstly isolated from Psidium guajava.
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