The Role of Ferritin Level and D-Dimer in Severity of SARS-Covid-2-Infected Patients in Al-Najaf Al-Ashraf Governorate

Background: The pandemic results of Coronavirus 2019 (COVID-19) range from moderate to serious, necessitating the rapid assessment and association of diagnostic markers. Patients suffer from infection with SARS-Covid-2 had measurements of ferritin, LDH, and D-dimer. In addition to being a problem for healthcare institutions, the SARS-Covid-2 additionally represents a major financial burden. Aim: To assess the predictive importance of serum ferritin & D-dimer levels as predictors for individuals at risk of serious and fatal infection with SARS-Covid-2. Methods: This study designs as Case-control study was done at AL-Amal Specialized Hospital for Communicable Diseases in Al-Najaf, Iraq, during the period of June to August of 2023. Prior to their enrollment in the clinical study, every individual participants provided written consent. 44 samples which included 22 patients (8 men and 14 women) and 20 control (8 men and 14 women) and varying age groups from 28 to 76 years old—were reported to have symptoms of SARS-Covid-2 infection. Results: The present investigation reveals significant differences between the patient and control groups, as well as between the patient and control groups' age groups and sexes. Patients who are older have a higher age-related prevalence of severe SARS-Covid-2 infection. In total, 22 COVID-19 patients were incorporated into this research; 8 (36.4%) were male and 14 (63.6%) were female. In comparison, there were 8 (36.4%) male and 14 (63.6%) female among 22 healthy control individuals. According to the statistical analysis, there were statistically significant differences between the female and male patients. There wasn't a noticeable difference in the mean serum level of ferritin between the SARS-Covid-2 infected patients' group and the control group (μg/l). Conversely, it was highly significant difference in mean serum level of D-Dimer between the COVID-19 patient group and the control group (μg/l). Conclusion: The age-specific prevalence of severe SARS-Covid-2 infections increases in older adults age of patients: Females showed higher rates of infection than males. Higher level Serum of D-dimer and ferritin are linked with outcomes in patientsCovid-19. Significantly elevated ferritin and D-dimer levels in infection with SARS-Covid-2 recovered individuals, which may serve as SARS-Covid-2 diagnostic biomarkers.