阿尔茨海默病中的新型组蛋白翻译后修饰：目前的进展和影响。

IF 4.8 2区医学 Q1 GENETICS & HEREDITY

Clinical Epigenetics Pub Date : 2024-03-09 DOI:10.1186/s13148-024-01650-w

Yuanyuan Qin, Ping Yang, Wanhong He, Dongze Li, Lisha Zeng, Junle Li, Tingting Zhou, Juan Peng, Ling Cao, Wei Huang

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引用次数: 0

摘要

阿尔茨海默病（AD）的发病机制十分复杂，多项研究表明，组蛋白翻译后修饰，尤其是乙酰化，在其中发挥着重要作用。随着质谱和蛋白质组学的发展，越来越多的新型 HPTMs 被发现，包括乳酰化、巴豆酰化、β-羟基丁酰化、2-羟基异丁酰化、琥珀酰化和丙二酰化。这些新型 HPTMs 将物质代谢与基因调控紧密联系在一起，目前已有越来越多关于新型 HPTMs 与 AD 关系的相关研究。本综述总结了目前新型 HPTMs 在 AD 中的研究进展和意义，为深入了解 AD 的发病机制和开发新型药物提供了参考。

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Novel histone post-translational modifications in Alzheimer's disease: current advances and implications.

Alzheimer's disease (AD) has a complex pathogenesis, and multiple studies have indicated that histone post-translational modifications, especially acetylation, play a significant role in it. With the development of mass spectrometry and proteomics, an increasing number of novel HPTMs, including lactoylation, crotonylation, β-hydroxybutyrylation, 2-hydroxyisobutyrylation, succinylation, and malonylation, have been identified. These novel HPTMs closely link substance metabolism to gene regulation, and an increasing number of relevant studies on the relationship between novel HPTMs and AD have become available. This review summarizes the current advances and implications of novel HPTMs in AD, providing insight into the deeper pathogenesis of AD and the development of novel drugs.

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来源期刊

Clinical Epigenetics ONCOLOGY-

自引率

5.30%

发文量

150

期刊介绍： Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.