多发性硬化症并发先天性骨髓增生异常综合征：病例报告。

IF 5 2区医学 Q1 CLINICAL NEUROLOGY

Multiple Sclerosis Journal Pub Date : 2025-06-01 Epub Date: 2024-03-08 DOI:10.1177/13524585241235539

Konrad Kubicki, Dusan Stefoski

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引用次数: 0

摘要

在使用富马酸二甲酯（DMF）治疗多发性硬化症 1.5 年（8 年前曾静脉注射克拉德里滨，1 年前曾静脉注射纳他珠单抗）后，我们的病人患上了骨髓增生异常综合征（MDS）。最初的表现是中性粒细胞和淋巴细胞绝对计数严重下降。重复骨髓活检显示了新的不平衡易位（1 号染色体长臂和 7 号染色体短臂之间）。据我们所知，这是首例将先天性 MDS 与 DMF 和克拉利宾联系起来的病例报告，同时也提示多发性硬化症患者慎用免疫抑制剂。

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Iatrogenic myelodysplastic syndrome complicating multiple sclerosis: A case report.

After 1.5 years of treatment with dimethyl fumarate (DMF) for multiple sclerosis, preceded 8 years earlier by intravenous (IV) cladribine and 1 year earlier by natalizumab, our patient developed myelodysplastic syndrome (MDS). The initial manifestation was a severe drop in absolute neutrophil and lymphocyte counts. Repeat bone marrow biopsy demonstrated a new unbalanced translocation (between the chromosome 1 long arm and chromosome 7 short arm). This case report, to our knowledge, is the first linking iatrogenic MDS to DMF and cladribine, while also suggesting caution with immunosuppressants in multiple sclerosis patients.

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来源期刊

Multiple Sclerosis Journal 医学-临床神经学

CiteScore

10.90

自引率

6.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585