Konstantinos Prokopidis, Jordi Morwani-Mangnani, Garry McDowell, Gregory Y H Lip, Massimo Venturelli, Rajiv Sankaranarayanan, Masoud Isanejad
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A meta-analysis employing a random-effects model was used to compute the pooled effects (CRD42023418465). Overall, 16 studies were included in this systematic review and meta-analysis. Our main analysis showed that sarcopenia in HF was linked to significantly higher levels of BNP (MD: 87.76, 95% CI 20.74-154.78, I<sup>2</sup> = 61%, P = 0.01) and NT-proBNP (MD: 947.45, 95% CI 98.97-1795.93, I<sup>2</sup> = 35%, P = 0.03). Similarly, low ASM was associated with significantly higher levels of BNP (MD: 118.95, 95% CI 46.91-191.00, I<sup>2</sup> = 93%, P < 0.01) and NT-proBNP (MD: 672.01, 95% CI 383.72-960.30, I<sup>2</sup> = 2%, P < 0.01). The quality of the included cohort studies was considered moderate, using the binary AXIS checklist and the Cochrane Tool to Assess the Risk of Bias in Cohort Studies.</p><p><strong>Conclusions: </strong>In patients with HF, sarcopenia and reduced ASM are associated with considerably higher plasma levels of BNP and NT-proBNP. Future research is required to investigate whether sarcopenia may express dysregulated biomarkers of cardiac function.</p>","PeriodicalId":49287,"journal":{"name":"European Geriatric Medicine","volume":" ","pages":"893-901"},"PeriodicalIF":3.5000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377361/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sarcopenia is linked to higher levels of B-type natriuretic peptide and its N-terminal fragment in heart failure: a systematic review and meta-analysis.\",\"authors\":\"Konstantinos Prokopidis, Jordi Morwani-Mangnani, Garry McDowell, Gregory Y H Lip, Massimo Venturelli, Rajiv Sankaranarayanan, Masoud Isanejad\",\"doi\":\"10.1007/s41999-024-00950-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>Sarcopenia is linked to impaired physical function and exercise tolerance. 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引用次数: 0
摘要
目的：肌肉疏松症与身体功能和运动耐力受损有关。本系统综述和荟萃分析旨在研究肌肉疏松症和低附壁骨骼肌（ASM）与心力衰竭（HF）患者的心脏功能生物标志物--B 型钠尿肽（BNP）及其 N 端片段（NT-proBNP）之间的关系：从开始到 2023 年 5 月，利用 PubMed、Web of Science、Scopus 和 Cochrane Library 数据库对观察性研究进行了系统的文献检索。采用随机效应模型进行荟萃分析，计算汇总效应（CRD42023418465）。本系统综述和荟萃分析共纳入了 16 项研究。我们的主要分析表明，HF 中的肌肉疏松症与 BNP（MD：87.76，95% CI 20.74-154.78，I2 = 61%，P = 0.01）和 NT-proBNP（MD：947.45，95% CI 98.97-1795.93，I2 = 35%，P = 0.03）水平显著升高有关。同样，低 ASM 与 BNP（MD：118.95，95% CI 46.91-191.00，I2 = 93%，P <0.01）和 NT-proBNP（MD：672.01，95% CI 383.72-960.30，I2 = 2%，P <0.01）水平显著升高相关。根据二元 AXIS 检查表和科克伦队列研究偏倚风险评估工具，纳入的队列研究质量为中等：结论：在心房颤动患者中，肌肉疏松症和 ASM 降低与血浆中 BNP 和 NT-proBNP 水平显著升高有关。未来的研究需要探讨肌肉疏松症是否会导致心脏功能生物标志物失调。
Sarcopenia is linked to higher levels of B-type natriuretic peptide and its N-terminal fragment in heart failure: a systematic review and meta-analysis.
Aims: Sarcopenia is linked to impaired physical function and exercise tolerance. The aim of this systematic review and meta-analysis was to examine the association of sarcopenia and low appendicular skeletal muscle (ASM) with biomarkers of cardiac function, B-type natriuretic peptide (BNP) and its N-terminal fragment (NT-proBNP), in patients with heart failure (HF).
Methods and results: From inception until May 2023, a systematic literature search of observational studies was undertaken utilizing the PubMed, Web of Science, Scopus, and Cochrane Library databases. A meta-analysis employing a random-effects model was used to compute the pooled effects (CRD42023418465). Overall, 16 studies were included in this systematic review and meta-analysis. Our main analysis showed that sarcopenia in HF was linked to significantly higher levels of BNP (MD: 87.76, 95% CI 20.74-154.78, I2 = 61%, P = 0.01) and NT-proBNP (MD: 947.45, 95% CI 98.97-1795.93, I2 = 35%, P = 0.03). Similarly, low ASM was associated with significantly higher levels of BNP (MD: 118.95, 95% CI 46.91-191.00, I2 = 93%, P < 0.01) and NT-proBNP (MD: 672.01, 95% CI 383.72-960.30, I2 = 2%, P < 0.01). The quality of the included cohort studies was considered moderate, using the binary AXIS checklist and the Cochrane Tool to Assess the Risk of Bias in Cohort Studies.
Conclusions: In patients with HF, sarcopenia and reduced ASM are associated with considerably higher plasma levels of BNP and NT-proBNP. Future research is required to investigate whether sarcopenia may express dysregulated biomarkers of cardiac function.
期刊介绍：
European Geriatric Medicine is the official journal of the European Geriatric Medicine Society (EUGMS). Launched in 2010, this journal aims to publish the highest quality material, both scientific and clinical, on all aspects of Geriatric Medicine.
The EUGMS is interested in the promotion of Geriatric Medicine in any setting (acute or subacute care, rehabilitation, nursing homes, primary care, fall clinics, ambulatory assessment, dementia clinics..), and also in functionality in old age, comprehensive geriatric assessment, geriatric syndromes, geriatric education, old age psychiatry, models of geriatric care in health services, and quality assurance.
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