甘油三酯-葡萄糖指数是预测冠状动脉疾病严重程度的重要指标:一项回顾性队列研究

IF 2.3 4区 医学 Q2 HEMATOLOGY
Xu Geng, Xi Zhang, XiaoWei Li, ChunTing Zhong, Min Hou
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引用次数: 0

摘要

背景和目的:冠状动脉疾病(CAD)的诊断标准是冠状动脉造影术(CAG)。由于冠状动脉造影术(CAG)是一项侵入性检查,因此需要确定非侵入性、有效和创新的生物标志物。我们的研究旨在回顾性分析预测 CAD 严重程度的血液标记物:我们收集了 195 名入院接受 CAG 治疗的 CAD 患者的病例数据。根据 Gensini 评分,患者被分为轻度、中度和重度 CAD 组。对血液指标和甘油三酯-葡萄糖(TyG)指数的预测效果进行了回顾性分析。在 195 例 CAD 患者中,81 例为轻度 CAD,60 例为中度 CAD,54 例为重度 CAD。三组患者的性别、空腹血糖(FBG)、TyG 指数和高敏 C 反应蛋白(hs-CRP)均有显著差异。与轻度 CAD 患者(8.75[8.49-9.14])相比,中度(9.07[8.62-9.44])和重度(8.98[8.46-9.45])CAD 患者的 TyG 指数值更高。TyG 指数的 AUC 为 0.615(95% 置信区间 (CI):0.536-0.694,P =.004),临界值为 8.997,特异性为 0.704,灵敏度为 0.535。物流分析表明,按 TyG 指数最佳临界值 8.997 重新分组后,中度和重度 CAD 的风险几率比 (OR) 值为 2.595(95% CI:1.199-5.619,调整后 P = .016)。TyG指数与FBG和hs-CRP组合的AUC值较高,明显高于其他组合(P = .011和0.02):结论:CAD 的严重程度与 TyG 指数值的增加呈正相关。结论:CAD 的严重程度与 TyG 指数值的升高呈正相关。TyG、FBG 和 hs-CRP 的组合提高了诊断效率,表明其有可能成为预测和诊断 CAD 进展的新指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Triglyceride-glucose Index as a Valuable Marker to Predict Severity of Coronary Artery Disease: A Retrospective Cohort Study.

Background and aims: The diagnostic standard of coronary artery disease (CAD) is coronary angiography (CAG). Since CAG is an invasive procedure underscores the need for identifying non-invasive, effective, and innovative biomarkers. Our study aimed to retrospectively analyze hematological markers for predicting the severity of CAD.

Methods and results: Case data were collected from 195 CAD patients admitted to the hospital for CAG. According to Gensini score, patients were divided into mild, moderate, and severe CAD groups. Blood indexes and predictive efficacy of the triglyceride-glucose (TyG) index were retrospectively analyzed. Among 195 CAD patients, 81 had mild CAD, 60 had moderate CAD, and 54 had severe CAD. Sex, fast blood glucose (FBG), TyG index, and high-sensitivity C-reactive protein (hs-CRP) significantly differed among the three groups. The TyG index demonstrated higher values in patients with moderate (9.07[8.62-9.44]) and severe (8.98[8.46-9.45]) CAD compared to those with mild CAD (8.75[8.49-9.14]). The AUC of the TyG index was 0.615 (95% confidence interval (CI): 0.536-0.694, P =.004), with a cut-off value of 8.997, specificity of 0.704, and sensitivity of 0.535. Logistics analysis showed the risk of moderate and severe CAD with an odds ratio (OR) value of 2.595 (95% CI: 1.199-5.619, adjusted P = .016) following regrouping by the TyG index optimal cut-off value of 8.997. The TyG index combined with FBG and hs-CRP had an elevated AUC value, significantly higher than other combinations (P  =  .011 and 0.02, respectively).

Conclusions: The severity of CAD is positively correlated with an increased TyG index value. A combination of TyG, FBG, and hs-CRP has demonstrated improved diagnostic efficiency, suggesting its potential as a novel indicator for predicting and diagnosing CAD progression.

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来源期刊
CiteScore
4.40
自引率
3.40%
发文量
150
审稿时长
2 months
期刊介绍: CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.
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