定量蛋白质质谱数据在单克隆抗体膜结合目标参与早期预测分析中的应用

IF 5.6 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

mAbs Pub Date : 2024-03-04 DOI:10.1080/19420862.2024.2324485

Armin Sepp, Morris Muliaditan

引用次数: 0

摘要

以模型为依据的药物发现提倡使用数学建模和模拟来提高药物发现的有效性。在针对细胞膜和细胞核的单克隆抗体（mAbs）的研究中，模型启发式药物发现是一种有效的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies

Model-informed drug discovery advocates the use of mathematical modeling and simulation for improved efficacy in drug discovery. In the case of monoclonal antibodies (mAbs) against cell membrane an...

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来源期刊

mAbs 工程技术-仪器仪表

CiteScore

10.70

自引率

11.30%

发文量

审稿时长

6-12 weeks

期刊介绍： mAbs is a multi-disciplinary journal dedicated to the art and science of antibody research and development. The journal has a strong scientific and medical focus, but also strives to serve a broader readership. The articles are thus of interest to scientists, clinical researchers, and physicians, as well as the wider mAb community, including our readers involved in technology transfer, legal issues, investment, strategic planning and the regulation of therapeutics.