雌激素相关受体α：老年性黄斑变性的潜在调节剂

IF 4 3区医学 Q1 PHARMACOLOGY & PHARMACY

Current Opinion in Pharmacology Pub Date : 2024-03-05 DOI:10.1016/j.coph.2024.102439

Fatima Massare Somers , Goldis Malek

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引用次数: 0

摘要

要开发出治疗老年性黄斑变性（AMD）等复杂致盲疾病的有效疗法，就必须确定其发生和发展的机制。雌激素相关受体α（ESRRA）是一种孤儿核受体，可调节多种与老年性黄斑变性相关的致病途径。然而，目前尚未对其在眼球后极老化或 AMD 中的作用进行详细研究。这篇综述深入探讨了 ESRRA 作为一个分子靶点的重要性，它可能在老年性黄斑变性的病理生物学中具有重要作用，并讨论了支持将该受体信号通路作为老年性黄斑变性治疗靶点的现有数据。

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Estrogen related receptor alpha: Potential modulator of age-related macular degeneration

To develop effective therapies for complex blinding diseases such as age-related macular degeneration (AMD), identification of mechanisms involved in its initiation and progression is needed. The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor that regulates several AMD-associated pathogenic pathways. However, it has not been investigated in detail in the ocular posterior pole during aging or in AMD. This review delves into the literature highlighting the significance of ESRRA as a molecular target that may be important in the pathobiology of AMD, and discusses data available supporting the targeting of this receptor signaling pathway as a therapeutic option for AMD.

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来源期刊

Current Opinion in Pharmacology 医学-药学

CiteScore

8.80

自引率

2.50%

发文量

131

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Pharmacology (COPHAR) publishes authoritative, comprehensive, and systematic reviews. COPHAR helps specialists keep up to date with a clear and readable synthesis on current advances in pharmacology and drug discovery. Expert authors annotate the most interesting papers from the expanding volume of information published today, saving valuable time and giving the reader insight on areas of importance.