通过 EPAC1 控制棕色脂肪组织的大小

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2024-03-04 DOI:10.1038/s41574-024-00971-3

Francesc Villarroya, Marta Giralt

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引用次数: 0

摘要

Reverte-Salisa及其同事的一项新研究发现了一种分子机制，cAMP介导蛋白EPAC1通过这种机制控制棕色和米色脂肪组织的大小。这一发现为开发药物干预打开了大门，以防止棕色脂肪组织在肥胖和老化过程中减少，从而改善代谢健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Controlling brown adipose tissue size through EPAC1

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Controlling brown adipose tissue size through EPAC1

A new study by Reverte-Salisa and colleagues identifies a molecular mechanism through which the cAMP-mediating protein EPAC1 controls the size of brown and beige adipose tissue. This finding opens the door for the development of pharmacological interventions to prevent the decline of brown adipose tissue in obesity and ageing, and thereby improve metabolic health.

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.