Allison Armstrong, Jane W Liang, Danton Char, Seth A Hollander, Kimberly A Pyke-Grimm
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引用次数: 0
摘要
背景：以前曾观察到小儿心脏移植结果因社会经济地位（SES）而存在差异。然而，随着移植疗法的进步和人们对健康差异认识的提高，有必要在现代环境中重新评估这些关联。这项回顾性研究旨在调查 SES 与小儿心脏移植患者预后之间的关系：方法：研究人员通过病历回顾收集了 2013 年至 2021 年期间在一个中心接受首次正位心脏移植手术（OHT）的 176 名儿科患者的数据。地区贫困指数（ADI）是基于美国人口普查数据的综合评分，用于量化社会经济地位。采用 Cox 比例危险模型和广义线性模型分析 SES 与移植物失败、排斥率和住院率之间的关系：分析结果显示，在我们的单中心研究中，低社会经济地位和高社会经济地位的小儿心脏移植患者在移植失败率、排斥率和住院率方面没有明显的统计学差异：结论：患者教育、政策和社会资源可能有助于减轻基于社会经济地位的医疗差异。需要开展更多的多中心研究，以确定能促进患者公平的移植后护理。
The effect of socioeconomic status on pediatric heart transplant outcomes at a single institution between 2013 and 2022.
Background: Disparities in pediatric heart transplant outcomes based on socioeconomic status (SES) have been previously observed. However, there is a need to reevaluate these associations in contemporary settings with advancements in transplant therapies and increased awareness of health disparities. This retrospective study aims to investigate the relationship between SES and outcomes for pediatric heart transplant patients.
Methods: Data were collected through a chart review of 176 pediatric patients who underwent first orthotopic heart transplantation (OHT) at a single center from 2013 to 2021. The Area Deprivation Index (ADI), a composite score based on U.S. census data, was used to quantify SES. Cox proportional hazards models and generalized linear models were employed to analyze the association between SES and graft failure, rejection rates, and hospitalization rates.
Results: The analysis revealed no statistically significant differences in graft failure rates, rejection rates, or hospitalization rates between low-SES and high-SES pediatric heart transplant patients for our single-center study.
Conclusion: There may be patient education, policies, and social resources that can help mitigate SES-based healthcare disparities. Additional multi-center research is needed to identify post-transplant care that promotes patient equity.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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