Phuong Anh Ton Nu , Thi Minh Chau Ngo , Cao Le Chi , Thị Bich Thao Do , Giang Tran Thi , Thị Ngoc Thuy Ha , Phuoc Vinh Nguyen , Minh Tam Le
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引用次数: 0
摘要
nivariensis 念珠菌是一种高度耐药的光滑念珠菌复合体，可引起侵袭性和皮肤黏膜感染。本研究描述了三例由 nivariensis 念珠菌引起的外阴阴道念珠菌病，并通过内部转录间隔 1-2 测序进行了鉴定。所有分离株在体外均对阿尼芬净、米卡芬净、卡泊芬净、5-氟胞嘧啶、泊沙康唑、伏立康唑、伊曲康唑、两性霉素 B 敏感，并对氟康唑表现出剂量依赖性敏感。有两名患者口服三次氟康唑均有效，但有一名患者对氟康唑产生了临床耐药性，6 个月后再次复发。增加氟康唑的每周剂量对该患者有效。
Three cases of vulvovaginal candidiasis due to Candida nivariensis
Candida nivariensis is emerging as a highly resistant species of the Candida glabrata complex causing invasive and mucocutaneous infections. In this study, three cases of vulvovaginal candidiasis caused by C. nivariensis are described and identified by Internal Transcribed Spacer 1–2 sequencing. All isolates were susceptible in vitro to anidulafungin, micafungin, caspofungin, 5-flucytosine, posaconazole, voriconazole, itraconazole, amphotericin B, and showed dose-dependent susceptibility to fluconazole. In two patients, three doses of oral fluconazole were effective, while one patient developed clinical fluconazole resistance with a new relapse after 6 months. Increasing the weekly dose of fluconazole showed to be effective in this patient.
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