保罗-伯格与 DNA 重组的起源。

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2024-02-29 DOI:10.1016/j.cell.2024.01.007

Doogab Yi, Janet E Mertz

引用次数: 0

摘要

1972 年秋，保罗-伯格实验室在《美国科学院院刊》（PNAS）上发表文章，介绍了两种体外构建重组 DNA 的方法。由于这一里程碑式的成就，他获得了 1980 年诺贝尔化学奖的一半奖金。在这里，我们将介绍这一发现是如何产生的，它给生物研究和制药业带来了革命性的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Paul Berg and the origins of recombinant DNA.

In fall 1972, Paul Berg's laboratory published articles in PNAS describing two methods for constructing recombinant DNAs in vitro. He received half of the 1980 Nobel Prize in Chemistry for this landmark accomplishment. Here, we describe how this discovery came about, revolutionizing both biological research and the pharmaceutical industry.

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.