腭部复发性多形性腺瘤的临床表现:系统综述。

Acta cirurgica brasileira Pub Date : 2024-02-26 eCollection Date: 2024-01-01 DOI:10.1590/acb390824
Gabriela Lopes-Santos, Najara Gomes de Oliveira Marques, Kellen Cristine Tjioe, Denise Tostes Oliveira
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引用次数: 0

摘要

目的:这篇系统综述分析了腭复发性多形性腺瘤的临床表现和恶变几率:方法:对腭部复发性多形性腺瘤患者进行系统回顾。数据库检索:MEDLINE、Scopus、Web of Science、Cochrane、EMBASE、Virtual Health Library、Google Scholar 和 OpenGrey。采用二项式逻辑回归评估原发肿瘤治疗后5年、10年和20年发现复发的几率:在 336 项研究中,有 13 项研究(n = 18 名患者)被纳入。腭部复发性多形性腺瘤多见于女性(61.6%),平均年龄为 49 岁(9-73 岁不等)。有 4 名患者发展为恶性肿瘤。原发性多形性腺瘤治疗后10年(OR=5.57;95%置信区间-95%CI 1.13-27.52)和20年(OR=18.78;95%CI 3.18-110.84)发现复发的几率(OR)明显高于一年随访时的几率:结论:腭部多形性腺瘤复发仍是一种罕见的晚期病变。结论:腭部多形性腺瘤复发仍是晚期发生的罕见病例,主要影响中年女性,并有恶变风险。腭多形性腺瘤虽然并不常见,但患者应警惕肿瘤晚期复发或恶变的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Clinical behavior of recurrent pleomorphic adenoma in the palate: a systematic review.

Purpose: This systematic review analyzed the clinical behavior and odds of malignancy of the palatal recurrent pleomorphic adenomas.

Methods: Systematic review of patients with recurrent pleomorphic adenoma arising in the palate. Database search: MEDLINE, Scopus, Web of Science, Cochrane, EMBASE, Virtual Health Library, Google Scholar, and OpenGrey. A binomial logistic regression was performed to assess the odds of detecting recurrence five, 10 and 20 years after the treatment of primary tumor.

Results: Thirteen studies (n = 18 patients) out of 336 were included. The recurrent pleomorphic adenoma in palate was more common in females (61.6%), average age was 49 years old (range 9-73 years old). Four patients progressed to malignant transformation. The odds ratio (OR) of detecting a recurrence at 10 (OR = 5.57; 95% confidence interval - 95%CI 1.13-27.52), and 20 years (OR = 18.78; 95%CI 3.18-110.84) after treatment of primary pleomorphic adenoma was significantly higher than at one-year follow-up.

Conclusions: The recurrence of pleomorphic adenoma in palate remains a rare event of late occurrence. It mainly affects middle-aged female and carries a risk of malignant transformation. Although uncommon, patients with palatal pleomorphic adenoma should be warned about the possibility of recurrence or malignant transformation of tumor at advanced ages.

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