RADA16 自组装肽 PuraStat® 用于腹腔镜妇科手术止血的有效性和可行性：试点研究。

IF 1.4 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Australian & New Zealand Journal of Obstetrics & Gynaecology Pub Date : 2024-02-29 DOI:10.1111/ajo.13798

Philip Hall

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引用次数: 0

摘要

腹腔镜妇科手术后出血仍是一种潜在的并发症。我们在一项试点研究中评估了 RADA16（PuraStat®），这是一种局部自组装多肽止血剂，有 46 名妇女接受了腹腔镜妇科手术。主要结果是切除部位出血的术中止血效果。在所有术中出血情况下（40/40 名参与者：100%）都能止血，没有出现临床上明显的手术床出血或并发症。止血的平均用量和所需时间分别为 6 毫升和 14 秒。这项研究表明，在腹腔镜妇科手术中，PuraStat® 是一种安全、有效的止血剂。有必要进行随机对照试验来证实这些研究结果。

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Efficacy and feasibility of the RADA16 self-assembling peptide, PuraStat® for haemostasis in laparoscopic gynaecological surgery: A pilot study

Bleeding after laparoscopic gynaecological surgery remains a potential complication. We assessed RADA16 (PuraStat®), a topical self-assembling peptide haemostatic agent, in a pilot study of 46 women undergoing laparoscopic gynaecological surgery. The primary outcome was intraoperative haemostatic efficacy for resection site bleeding. Haemostasis was achieved in all intraoperative bleeding situations (40/40 participants: 100%) with no clinically significant surgical bed bleeding or complications. Mean volume and time required to achieve haemostasis were 6 mL and 14 sec, respectively. This study suggests that PuraStat® is a safe, effective haemostatic agent in laparoscopic gynaecological surgery. Randomised controlled trials are warranted to confirm these findings.

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来源期刊

Australian & New Zealand Journal of Obstetrics & Gynaecology 医学-妇产科学

CiteScore

3.40

自引率

11.80%

发文量

165

审稿时长

4-8 weeks

期刊介绍： The Australian and New Zealand Journal of Obstetrics and Gynaecology (ANZJOG) is an editorially independent publication owned by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) and the RANZCOG Research foundation. ANZJOG aims to provide a medium for the publication of original contributions to clinical practice and/or research in all fields of obstetrics and gynaecology and related disciplines. Articles are peer reviewed by clinicians or researchers expert in the field of the submitted work. From time to time the journal will also publish printed abstracts from the RANZCOG Annual Scientific Meeting and meetings of relevant special interest groups, where the accepted abstracts have undergone the journals peer review acceptance process.