使用简化银屑病指数评估血清鳞状细胞癌抗原水平与皮肤银屑病严重程度的相关性

IF 3.1 4区 医学 Q2 DERMATOLOGY
D. Henry , A. Alkhars , M. Samimi , D. Dufour , L. Machet
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引用次数: 0

摘要

背景鳞状细胞癌抗原(SCCA)是鳞状细胞癌疾病进展的生物标志物,同时也是银屑病的发病机制之一。之前的八项研究显示,使用银屑病评估严重程度指数或体表面积评估的银屑病严重程度与通过非商业测试评估的血清 SCCA(主要是 SCCA2)水平之间存在相关性。我们研究了使用商业试剂盒测量的血清 SCCA 水平与使用银屑病简化指数 (SPI) 评估的银屑病严重程度之间的相关性。研究的主要终点是当天测量的血清 SCCA 水平,以及基线和随访期间专业版 SPI(proSPI-s)的银屑病严重程度评分。次要终点是当天测量的血清SCCA水平和proSPI社会心理评分(proSPI-p)、proSPI治疗评分、皮肤科生活质量指数(DLQI)以及炎症参数(C反应蛋白水平、中性粒细胞与淋巴细胞比率)。血清 SCCA 水平与基线和随访时的 proSPI-s 相关(Spearman r = 0.686 和 r = 0.674,p < 0.0001)。它与proSPI-p和DLQI相关。血清 SCCA 水平与中性粒细胞与淋巴细胞比率(r = 0.083)或 C 反应蛋白水平(r = 0.192)均无相关性。此外,SCCA 是通过一种广泛使用的试剂盒测定的。SCCA 可用于评估银屑病的严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation of serum level of squamous cell carcinoma antigen with severity of cutaneous psoriasis, assessed using the simplified psoriasis index

Background

Squamous cell carcinoma antigen (SCCA) is a biomarker of disease progression in squamous cell carcinoma but also contributes to the pathogenesis of psoriasis. Eight previous studies have shown a correlation between psoriasis severity, assessed using the Psoriasis Assessment Severity Index or body surface area, and serum level of SCCA, mainly SCCA2, assessed by means of non-commercial tests. We examined the correlation between serum SCCA level, measured with a commercial kit, and psoriasis severity assessed using the Simplified Psoriasis Index (SPI).

Methods

We conducted a prospective, non-interventional, single-centre study at the University Hospital of Tours over 18 months. The primary endpoint was same-day measurement of serum SCCA level and the psoriasis severity score on the professional version of the SPI (proSPI-s) at both baseline and follow-up. Secondary endpoints were same-day measurement of serum SCCA level and the proSPI psychosocial score (proSPI-p), proSPI treatment score, Dermatology Life Quality Index (DLQI), and inflammation parameters (C-reactive protein level, neutrophil-to-lymphocyte ratio).

Results

We included 50 psoriasis patients. Serum SCCA level was correlated with the proSPI-s at baseline and follow-up (Spearman r = 0.686 and r = 0.674, p < 0.0001) for both. It was correlated with the proSPI-p and DLQI. Serum SCCA level was not correlated with either neutrophil-to-lymphocyte ratio (r = 0.083) or C-reactive protein level (r = 0.192).

Conclusion

This study is the first to correlate serum SCCA level with proSPI-s. Moreover, SCCA was measured using a widely available kit. SCCA may be used to assess the severity of psoriasis.

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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
70
审稿时长
81 days
期刊介绍: Les Annales de dermatologie sont le rendez-vous mensuel incontournable de toute la dermatologie francophone, grâce à leur comité de rédaction qui assure une sélection rigoureuse des articles selon les normes de l''édition scientifique internationale. Une revue didactique, véritable aide à la pratique médicale quotidienne Pour compléter et enrichir la partie scientifique, la rubrique Formation médicale continue propose aux lecteurs des textes didactiques et interactifs (Cas pour diagnostic, Notes de pharmacovigilance, la Question du praticien, Dermatologie chirurgicale, la Sélection bibliographique du mois...) qui les font bénéficier d''une formation post-universitaire diversifiée et de qualité. La revue consacre également un espace pour la publication de questions des lecteurs auxquelles des experts apportent une réponse.
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