解读口腔-肠道轴:牙周炎与 IBD 之间的相互联系、当前挑战和未来展望。

Himanshi Tanwar, Jeba Mercy Gnanasekaran, Devon Allison, Ling-Shiang Chuang, Xuesong He, Mario Aimetti, Giacomo Baima, Massimo Costalonga, Raymond K Cross, Cynthia Sears, Saurabh Mehandru, Judy Cho, Jean-Frederic Colombel, Jean-Pierre Raufman, Vivek Thumbigere-Math
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引用次数: 0

摘要

作为口腔消化道的两端,口腔和肠道在解剖学、微生物学和免疫学方面有着共同的联系,对健康有着双向的影响。越来越多的证据表明,口腔病变与炎症性肠病(IBD)之间存在相互联系,这意味着传统的独立疾病概念已转变为复杂的相互循环。本综述概述了支持 "口腔-肠道 "轴的证据,其特点是 IBD 患者的牙周炎和其他口腔疾病发病率较高,反之亦然。我们深入探讨了口腔病变与 IBD 之间的相互联系,强调了共同的微生物和免疫学途径,并提出了牙周炎介导的肠道炎症发病机制中的 "多重打击 "假说。此外,这篇综述还强调了牙科医生和肠胃病学家合作提供口腔-系统整体医疗保健的迫切需要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unravelling the Oral-Gut Axis: Interconnection Between Periodontitis and Inflammatory Bowel Disease, Current Challenges, and Future Perspective.

As the opposite ends of the orodigestive tract, the oral cavity and the intestine share anatomical, microbial, and immunological ties that have bidirectional health implications. A growing body of evidence suggests an interconnection between oral pathologies and inflammatory bowel disease [IBD], implying a shift from the traditional concept of independent diseases to a complex, reciprocal cycle. This review outlines the evidence supporting an 'oral-gut' axis, marked by a higher prevalence of periodontitis and other oral conditions in IBD patients and vice versa. We present an in-depth examination of the interconnection between oral pathologies and IBD, highlighting the shared microbiological and immunological pathways, and proposing a 'multi-hit' hypothesis in the pathogenesis of periodontitis-mediated intestinal inflammation. Furthermore, the review underscores the critical need for a collaborative approach between dentists and gastroenterologists to provide holistic oral-systemic healthcare.

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