从献血者中糖尿病患病率看 SARS-CoV-2 感染和接种疫苗后长期并发症的最新模式和评估。

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Turki Mohammed M Alqahtani, Mohammed Abdullah Ali Alghamdi, Mirza Rafi Baig, Fahad A Al-Abbasi, Ryan Adnan Sheikh, Naif A R Almalki, Moayad Mustafa Hejazi, Sultan Alhayyani, Turky Omar Asar, Vikas Kumar, Firoz Anwar
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引用次数: 0

摘要

背景:越来越多的证据表明,SARS-CoV-2 疫苗接种后的长期并发症包括糖尿病。关于 1 型糖尿病的风险和负担已有大量报道,但 2 型糖尿病(T2D)的特征尚未确定。为了填补这一空白,我们旨在研究沙特人感染 SARS-CoV-2 和接种疫苗后糖尿病发病率的长期并发症趋势:在这项以医院为基础的横断面研究中,我们分析了吉达市阿卜杜勒-阿齐兹国王大学附属医院首次献血者的血液特征。沙特阿拉伯。在 2023 年 5 月测量了各种血液参数和 HbA1c。所有献血者均无糖尿病,且在献血前从未被诊断出患有 T2D。203 名健康受试者献血,其中 104 人的 HbA1c 异常偏高,倾向于诊断为 T2D,99 人的血液指标正常。研究遵循了 STROBE 报告指南:在 203 名献血者中,104 人(男性 50 人,占 48.1%;女性 54 人,占 51.9%)被诊断为 HbA1c 增高(男性为 8.24,女性为 7.61)。35.6%的人年龄在 65 岁以上,52.9%的人 ABO 血型为 O+。肝功能显示,在 HbA1c 升高的供血者中,GGT(46.47 U/L)和碱性磷酸酶(99.93 ±64.26 uL)分别明显升高(p˂0.05、0.04),而 KFT 则明显升高(p˂0.05、0.02),尿素(6.73±5.51mmol/L)、肌酐(129.97±195.17umol/L),以及乳酸脱氢酶(LDH)(263.72±196.70uL)和甘油三酯(1.66±0.74mmol/L)的升高:在本横断面研究中,感染 SARS-CoV-2 和接种疫苗后,HbA1c 明显升高,T2D 病例呈上升趋势。与女性相比,男性受影响更大。此外,SARS-CoV-2 感染后和接种疫苗后的献血者中,65 岁以上献血者的部分 LFT(谷丙转氨酶、碱性磷酸酶)、KFT(尿素、肌酐)、血脂(TG)和 LDH 发生变化的病例数最多:结论:50% 的献血者(不分男女)的 HbA1c 升高是一个令卫生当局震惊的数字,同时 LFT、KFT 和 LDH 检测也发生了变化,在不久的将来,这可能会增加 T2D 的发病率。需要进行大规模的人群研究,以防止今后接种疫苗的幼儿发生 T2D。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Patterns and Assessment of Long-term Complications followi ngSARS-CoV-2 Infection and Vaccination in the Context of Diabet esPrevalence among Blood Donors.

Background: Much increasing evidence has suggested that long-term complications post vaccination of SARS-CoV-2 experience a wide range of complication including diabetes. The risk and burden of type 1 diabetes is extensively reported, but type 2 diabetes mellitus (T2D) has yet to be characterized. To address this gap, we aimed to examine trends of long-term complications post SARS-CoV-2 infection and vaccination in diabetes incidence among the Saudi population.

Methods: In this cross-sectional hospital-based study, we analyzed the blood profile of first-time blood donors from the University Hospital of King Abdulaziz University, Jeddah. Saudi Arabia. Various blood parameters, HbA1c was measured in the month of May 2023. All the donors were non-diabetic and were never diagnosed with T2D before the current blood donation. 203 healthy subjects donated their blood, out of which 104 had abnormally high HbA1c tending towards diagnosis of T2D and 99 had with blood profiles. The study followed the STROBE reporting guidelines.

Results: Out of 203 donors 104 (male 50(48.1%), female 54(51.9%)) were diagnosed with increased HbA1c (8.24 in males) compared to 7.61 of HbA1c in females. 35.6% were above ˃65 years, with 52.9% with O+ from the ABO blood group. Liver functions indicated significant p˂0.05, 0.04, increased amount of GGT (46.47 U/L), Alkaline phosphatase (99.93 ±64.26 uL) respectively in HbA1c elevated donors KFT represented significant p˂0.05, 0.02 elevated levels of urea (6.73 ±5.51 mmol/L), creatinine (129.97 ±195.17 umol/L) respectively along with elevated values of Lactate dehydrogenase (LDH) (263.72± 196.70 uL) and triglycerides (1.66 ±0.74mmol/L) when compared to normal value of HbA1c donors.

Discussion: In the present cross-sectional study, significant increase in HbA1c, trending towards increased cases of T2D post SARS-CoV-2 infection and vaccination. Males are much affected compared to females. Further maximum number of cases were from donors above the age of 65 years with altered partial LFT (GGT, Alkaline phosphatase), KFT (urea, creatinine), lipid profile (TG) and LDH in post SARS-CoV-2 and vaccination blood donors.

Conclusion: Increase in HbA1c in 50% of donors, irrespective of gender, is an alarming figure for health authorities, with altered LFT, KFT and LDH tests and, in the near future, may increase the incidence of T2D. Large-scale population-based studies are required to prevent future incidences of T2D in young children who will be vaccinated.

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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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