摄入纯咖啡因粉自杀。公共卫生面临的新挑战?

Neuro endocrinology letters Pub Date : 2019-10-08
Jozef Sidlo, Jan Sikuta, Henrieta Sidlova, Lubos Niznansky
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引用次数: 0

摘要

目的:因过量摄入能量饮料而有意或无意滥用咖啡因的现象屡见不鲜。因咖啡因中毒而导致死亡的案例很少见。在过去几年中,科学文献中出现过以自杀为目的而摄入咖啡因的病例:本病例研究旨在报告一起 26 岁男子故意摄入纯咖啡因粉致死的病例:方法:采用筛选法、TLC、GC 和 GC/MS 进行标准尸检、显微镜检查和毒理学检查:结果:血液中咖啡因浓度为 362 微克/毫升,尿液中咖啡因浓度为 187 微克/毫升。死亡原因很可能是室性心律失常导致心脏骤停。死者股部血液中的咖啡因浓度比其他已发表的案例研究中报告的致死浓度高出三倍。根据调查情况,死亡方式被评估为自杀。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Suicides by ingestion of pure caffeine powder. New challenge for public health?

Objectives: Intentional or unintentional caffeine abuse due to excessive intake of energy beverages is frequent. Fatalities due to caffeine intoxication are presented rarely. Over the last years, cases of caffeine ingestion for purposes of committing suicide have been reported in scientific literature.

Design: The aim of this case study is to report a fatal case of a 26-year-old man who intentionally ingested pure caffeine powder.

Methods: Standard autopsy, microscopic examination and toxicological examination using screening method, TLC, GC, and GC/MS were performed.

Results and conclusions: The presence of caffeine only at the concentration of 362 ug/mL in blood and 187 ug/mL in urine was revealed. The cause of death was cardiac arrest most likely due to ventricular dysrhythmia. The concentration of caffeine determined in the femoral blood of the decedent was three times higher than the lethal concentrations reported in other published case studies. Based on the investigated circumstances, the manner of death was evaluated as a suicide.

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