蜂蜜和大蒜水提取物对小鼠短期暴露于香烟烟草的影响:组织病理学和生物化学研究。

IF 3.4 Q2 TOXICOLOGY
Journal of Toxicology Pub Date : 2024-02-19 eCollection Date: 2024-01-01 DOI:10.1155/2024/5539447
Ziad Shraideh, Darwish Badran, Ahmed Alzbeede
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引用次数: 0

摘要

众所周知,吸烟会对人体健康产生不利影响,并诱发大多数重要器官的氧化应激。本研究旨在评估蜂蜜和大蒜提取物在改善小鼠短期暴露于香烟烟雾影响方面的生化、组织学和超微结构价值。研究人员将 48 只小鼠随机分为 6 组:I 组只暴露于新鲜空气中,II 组暴露于香烟烟雾中,III 组服用 0.2 毫升蜂蜜提取物,IV 组暴露于香烟烟雾中并服用 0.2 毫升蜂蜜提取物,V 组服用 0.2 毫升大蒜提取物,VI 组暴露于香烟烟雾中并服用 0.2 毫升大蒜水提取物。在连续 21 天的时间里,各处理组每天重复进行这些暴露。第三周结束时,对动物实施颈椎脱臼安乐死。抽取血液进行生化研究,并对所选的肝脏、肾脏和空肠器官进行组织学和超微结构研究。生化结果表明,实验小鼠短期暴露于吸烟环境中,除白蛋白水平下降外,肝功能检测没有其他变化。此外,吸烟会提高羰基蛋白含量和胱抑素 C 的浓度。从组织学角度来看,使用蜂蜜和大蒜对肝脏、肾脏和空肠有很好的保护作用,透射电子显微镜也证明了这一点,此外还能降低氧化应激生物标志物。总之,使用蜂蜜和/或大蒜有助于保护肝脏、肾脏和空肠免受香烟烟雾的危害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Honey and Aqueous Garlic Extracts against Short-Term Exposure of Cigarette Tobacco Smoking in Mice: Histopathological and Biochemical Investigations.

It is well known that cigarette smoking adversely affects human health and induces oxidative stress in most vital organs. This study aims to assess the biochemical, histological, and ultrastructural values of honey and garlic extracts in ameliorating the effects of short-term exposure to cigarette smoke in mice. Forty-eight mice were randomly divided into six equal groups: group I was exposed to fresh air only, group II was exposed to cigarette smoke, group III was given 0.2 ml of honey extract, group IV was exposed to cigarette smoke and was given 0.2 ml of honey extract, group V was given 0.2 ml of garlic extract, and group VI was exposed to cigarette smoke and was given 0.2 ml of aqueous garlic extract. These exposures were repeated daily for 21 consecutive days among the treated groups. By the end of the third week, the animals were euthanized by physical cervical dislocation. Blood was taken for biochemical study, and the selected organs of the liver, kidney, and jejunum were processed for histological and ultrastructural studies. The biochemical results showed that short-term exposure of experimental mice to cigarette smoking did not alter the liver function tests except for decreasing the albumin level. Moreover, cigarette smoking elevates the concentration of carbonyl protein content and cystatin C. Histologically, the use of honey and garlic showed good protection to the liver, kidney, and jejunum, which was proved by transmission electron microscopy, in addition to lowering the oxidative stress biomarkers. In conclusion, using honey and/or garlic helps protect the liver, kidney, and jejunum against the hazardous effects of cigarette smoke.

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来源期刊
Journal of Toxicology
Journal of Toxicology TOXICOLOGY-
CiteScore
5.50
自引率
3.40%
发文量
0
审稿时长
10 weeks
期刊介绍: Journal of Toxicology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of toxicological sciences. The journal will consider articles looking at the structure, function, and mechanism of agents that are toxic to humans and/or animals, as well as toxicological medicine, risk assessment, safety evaluation, and environmental health.
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