外泌体：癌症治疗的关键角色及其未来前景。

IF 1.6 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Assay and drug development technologies Pub Date : 2024-04-01 Epub Date: 2024-02-26 DOI:10.1089/adt.2023.026

Reena Gupta, Jitendra Gupta, Suchismita Roy

引用次数: 0

摘要

癌症是导致全球死亡的主要原因之一。随着人口的增加，为治疗癌症筛选一种更新的抗癌剂递送系统的要求越来越高。因此，外泌体介导的细胞通讯是其参与癌症转移和进展的标志。此外，内泌体向内出芽被称为多囊体。外泌体是磷脂双分子层结合的囊泡。它在各种细胞和肿瘤微环境之间传输生物活性化合物。此外，他们还选择性地将致癌分子装入外泌体以进行药物输送。外泌体是检测治疗目标的潜在生物标记物。此外，外泌体与细胞膜融合，可用作癌症治疗的诊断工具。外泌体可通过多种方式抑制癌细胞生长。它还可以携带遗传信息和抗癌药物，防止肿瘤细胞释放外泌体。此外，基于外泌体的药物输送被用于临床前和临床试验，促进了抑制癌症生长的新型抗癌药物的开发。外泌体可进一步改善免疫系统，帮助生成新血管。它能阻止细胞凋亡，防止癌症产生抗药性。外泌体作为货物，可以装载蛋白质、化疗药物、RNA、DNA 和疏水性药物。外泌体有助于通过使用精准医疗实现癌症管理的进步。本综述强调了外泌体在癌症机制和预防方面的重要作用。此外，还介绍了旨在促进外泌体在癌症诊断和治疗中的临床应用的新策略。最后，本综述对从事该领域工作的业界和学术界研究人员起着举足轻重的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Exosomes: Key Players for Treatment of Cancer and Their Future Perspectives.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Assay and drug development technologies 医学-生化研究方法

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application. ASSAY and Drug Development Technologies coverage includes: -Assay design, target development, and high-throughput technologies- Hit to Lead optimization and medicinal chemistry through preclinical candidate selection- Lab automation, sample management, bioinformatics, data mining, virtual screening, and data analysis- Approaches to assays configured for gene families, inherited, and infectious diseases- Assays and strategies for adapting model organisms to drug discovery- The use of stem cells as models of disease- Translation of phenotypic outputs to target identification- Exploration and mechanistic studies of the technical basis for assay and screening artifacts