Ibrahim-Ethem Celik , Fabia Mittendorf , Adrián Gómez-Suárez, Stefan F. Kirsch
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引用次数: 0
摘要
大环内酯类化合物 bastimolide A 是一个极具吸引力的合成目标，因为它对恶性疟原虫的抗药性菌株具有良好的活性。我们报告了 bastimolide A 的简单正式合成方法，该方法以 Horner-Wittig 试剂和来自同一手性池基中间体的醛为关键构件。
Formal synthesis of bastimolide A using a chiral Horner-Wittig reagent and a bifunctional aldehyde as key building blocks
The macrolide bastimolide A represents an attractive synthetic target due to its promising activity against resistant strains of the malaria pathogen plasmodium falciparum. We report a straightforward formal synthesis of bastimolide A using a Horner-Wittig reagent and an aldehyde derived from the same chiral-pool based intermediate as key building blocks.
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