纯化的甘比（uncaria gambir (Hunter) roxb.）减轻阿脲诱导的糖尿病雄性大鼠的肾功能

Q2 Pharmacology, Toxicology and Pharmaceutics

International Journal of Applied Pharmaceutics Pub Date : 2024-02-15 DOI:10.22159/ijap.2024.v16s1.34

Fitri Rachmaini, Armenia, Rahmad Abdillah

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引用次数: 0

摘要

目的：抗氧化剂可预防糖尿病及其血管并发症。纯化甘比为 Uncaria gambir (Hunter) Roxb 的纯化提取物，其中含有 90% 以上的儿茶素，具有科学的抗氧化作用。本研究旨在确定纯化甘比对阿脲诱导的 Wistar 京都糖尿病大鼠肾功能的影响。研究方法腹腔注射阿脲 125 毫克/千克体重诱导糖尿病大鼠。将45只糖尿病大鼠分为5组，分别为使用药物治疗的糖尿病对照组、使用剂量为0.45 mg/kgBW的格列本脲治疗的阳性对照组，以及使用剂量为2.50、5和10 mg/kgBW的纯化甘比三醇治疗组，连续治疗14天，分别在第3、7和14天测量血糖、饮水量、尿量、肌酐清除率、肾比值和尿液密度。所有数据均采用双因素方差分析，然后进行邓肯多重范围检验。结果纯化甘比可明显降低糖尿病大鼠的血糖（p<0.05），并对其肾功能参数有明显影响（p<0.05）。糖尿病大鼠服用纯化 gambir 的时间对水摄入量、尿量、肌酐清除率和肾脏比率有明显影响（p<0.05）。结论这一结果表明，剂量为 2.5 毫克/千克体重的纯化甘比可增强糖尿病大鼠的肾功能，相反，剂量为 5 毫克/千克体重和 10 毫克/千克体重的纯化甘比可减轻糖尿病大鼠的肾功能。

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PURIFIED GAMBIR (UNCARIA GAMBIR (HUNTER) ROXB.) ATTENUATE RENAL FUNCTION IN ALLOXAN-INDUCED DIABETIC MALE RATS

Objective: Diabetes and its vascular complications could prevent by antioxidants. Purified gambir is the purified extract of Uncaria gambir (Hunter) Roxb, which contains more than 90% catechins and scientifically work as antioxidant. This study aimed to determine the effect of purified gambir on renal function in alloxan-induced diabetic Wistar Kyoto rats. Methods: Diabetic rats were induced by alloxan 125 mg/kgBW by intraperitoneal injection. Forty-five diabetic rats were divided into five groups, diabetic control group treated with vehicle, a positive control group treated with glibenclamide at dose 0.45 mg/kgBW, and treatment groups of purified gambir at doses of 2.50, 5, and 10 mg/kgBW for 14 d. Blood glucose, water intake, urine volume, creatinine clearance, renal ratio, and urine density were measured on day 3, 7, and 14. All data were analyzed by two-way ANOVA followed by Duncan Multiple Range Test. Results: Purified gambir significantly lower blood glucose (p<0.05) and had a significant effect (p<0.05) on renal function parameters in diabetic rats. Duration of treatment purified gambir in diabetic rats had a significant effect (p<0.05) on water intake, urine volume, creatinine clearance and renal ratio. Conclusion: This result show that purified gambir at dose 2.5 mg/kgBW increased the renal function of diabetic rats, in contrast, purified gambir at dose 5 and 10 mg/kgBW attenuate renal function of diabetic rats

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来源期刊

International Journal of Applied Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.40

自引率

0.00%

发文量

219

期刊介绍： International Journal of Applied Pharmaceutics (Int J App Pharm) is a peer-reviewed, bimonthly (onward March 2017) open access journal devoted to the excellence and research in the pure pharmaceutics. This Journal publishes original research work that contributes significantly to further the scientific knowledge in conventional dosage forms, formulation development and characterization, controlled and novel drug delivery, biopharmaceutics, pharmacokinetics, molecular drug design, polymer-based drug delivery, nanotechnology, nanocarrier based drug delivery, novel routes and modes of delivery; responsive delivery systems, prodrug design, development and characterization of the targeted drug delivery systems, ligand carrier interactions etc. However, the other areas which are related to the pharmaceutics are also entertained includes physical pharmacy and API (active pharmaceutical ingredients) analysis. The Journal publishes original research work either as a Original Article or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication in the Journal.