甘油磷酸钙和Ca2+对兔肾髓质片前列腺素合成影响的比较。

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1985-01-01

T Fujita, H Kasatani, K Suzuki, Y Fujimoto

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摘要

比较了α -甘油磷酸钙(CaG)和Ca2+对髓质前列腺素E2生成的刺激作用。CaG (4mM)明显比Ca2+ (4mM)更有效地刺激前列腺素E2的释放。CaG的这种作用在外源性磷脂酶A2(0.1单位/ml)存在时最为明显。这些结果表明CaG对磷脂酶A2的高亲和力比Ca2+对前列腺素E2的形成具有更强的刺激作用。

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Comparison of the effects of calcium alpha-glycerophosphate and Ca2+ on prostaglandin synthesis in rabbit kidney medulla slices.

The stimulatory effects of calcium alpha-glycerophosphate (CaG) and Ca2+ on the generation of medullary prostaglandin E2 have been compared. CaG (4mM) was significantly more effective than Ca2+ (4 mM) as a stimulus for prostaglandin E2 release. This effect of CaG was most pronounced in the presence of exogenous phospholipase A2 (0.1 unit/ml). These results suggest that CaG has a more powerful stimulatory effect on prostaglandin E2 formation than Ca2+ because of its high affinity for phospholipase A2.

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Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

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