钙拮抗剂和抗痉挛药物对软体动物平滑肌乙酰胆碱收缩的影响。

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1985-01-01

H Murakami, T Ishikawa, H Watanabe

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引用次数: 0

摘要

观察钙拮抗剂和抗痉挛药物对乙酰胆碱和DMPP作用下收缩的影响。维拉帕米(10(-5)至10(-4)M)，地尔硫卓(10(-5)至10(-4)M)和D-600(10(-5)至10(-4)M)以剂量依赖性方式抑制两种收缩。罂粟碱(10(-5)至10(-4)M)和Aspaminol(10(-6)至10(-5)M)也以剂量依赖的方式抑制这两种收缩。这些发现表明，激活乙酰胆碱收缩的Ca2+是由外部介质和细胞内储存位点提供的。

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Effects of Ca-antagonists and antispasmodic drugs on contraction by ACh in molluscan smooth muscle.

The influence of Ca-antagonists and antispasmodic drugs on contractions by ACh and by DMPP were investigated. Verapamil (10(-5) to 10(-4) M), diltiazem (10(-5) to 10(-4) M) and D-600 (10(-5) to 10(-4) M) depressed both the contractions in a dose dependent manner. Papaverine (10(-5) to 10(-4) M) and Aspaminol (10(-6) to 10(-5) M) also depressed both the contractions in a dose dependent manner. These findings indicate that Ca2+, which initiates the contraction by ACh, is supplied from both the external medium and intracellular store sites.

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Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

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