超越抗药性：真菌病原体的抗真菌异抗性和抗真菌耐受性

IF 5.9 2区生物学 Q1 MICROBIOLOGY

Current opinion in microbiology Pub Date : 2024-02-23 DOI:10.1016/j.mib.2024.102439

Feng Yang , Judith Berman

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引用次数: 0

摘要

真菌感染在全球范围内日益增多，造成了惊人的高死亡率和经济负担。除了抗真菌抗药性，其他更微妙的药物反应似乎也增加了治疗失败的可能性。这些反应包括异抗性和耐受性，这些术语在抗菌药物中定义更为明确，但在致病真菌中也很明显。在这里，我们将这些抗真菌反应与类似的抗菌反应进行了比较，并回顾了我们在了解抗真菌异抗性和耐受性产生途径方面的最新进展。

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Beyond resistance: antifungal heteroresistance and antifungal tolerance in fungal pathogens

Fungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures. These responses include heteroresistance and tolerance, terms that are more well-defined for antibacterial drugs, but are also evident in pathogenic fungi. Here, we compare these antifungal responses with similarly named antibacterial responses, and we review recent advances in how we understand the routes by which antifungal heteroresistance and tolerance emerge.

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来源期刊

Current opinion in microbiology 生物-微生物学

CiteScore

10.00

自引率

0.00%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Microbiology is a systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of microbiology. It consists of 6 issues per year covering the following 11 sections, each of which is reviewed once a year: Host-microbe interactions: bacteria Cell regulation Environmental microbiology Host-microbe interactions: fungi/parasites/viruses Antimicrobials Microbial systems biology Growth and development: eukaryotes/prokaryotes