Alexandra J.E.M. de Reus , Onur Basak , Werner Dykstra , Jessy V. van Asperen , Emma J. van Bodegraven , Elly M. Hol
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引用次数: 0
摘要
神经胶质纤维酸性蛋白（GFAP）是一种在神经系统特定类型胶质细胞中表达的中间丝（IF）蛋白。在大脑发育和神经系统疾病中，GFAP 的表达受到高度调控。在各种细胞类型、发育阶段和疾病中存在不同的 GFAP-异构体，这表明 GFAP（转录后）调控在神经胶质细胞的生理和病理中发挥作用。GFAP 异构体在亚细胞定位、IF 网络组装特性和 IF 动力学方面存在差异，这导致了 IF 网络不同的分子相互作用和机械特性。因此，GFAP（转录后）调控可能是放射胶质细胞、星形胶质细胞和胶质瘤细胞调节细胞功能的一种机制。
GFAP-isoforms in the nervous system: Understanding the need for diversity
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly properties, and IF-dynamics which results in distinct molecular interactions and mechanical properties of the IF-network. Therefore, GFAP (post-)transcriptional regulation is likely a mechanism by which radial glia, astrocytes, and glioma cells can modulate cellular function.
期刊介绍：
Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings.
COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.
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