葛根素通过调节 PI3K/AKT 信号通路保护脂肪肝免受缺血再灌注损伤。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-02-19 eCollection Date: 2024-01-01 DOI:10.1590/1414-431X2024e13229

Faji Yang, Hengjun Gao, Zheyu Niu, Qingqiang Ni, Huaqiang Zhu, Jianlu Wang, Jun Lu

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引用次数: 0

摘要

非酒精性脂肪肝（NAFLD）的发病率居高不下，许多非酒精性脂肪肝患者患有严重的缺血再灌注损伤（IRI）。目前，还没有切实可行的方法来治疗 IRI。葛根素在治疗非酒精性脂肪肝、中风、糖尿病和高血压等多种疾病方面发挥着重要作用。然而，它在脂肪肝 IRI 中的作用仍不明确。我们旨在探讨葛根素是否能保护脂肪肝免受IRI的影响。用高脂饮食（HFD）喂养 C57BL/6J 小鼠，然后进行缺血再灌注损伤。结果表明，与正常肝脏相比，脂肪肝的肝脏IRI更为严重，而葛根素能显著保护脂肪肝免受IRI，并减轻氧化应激。PI3K-AKT信号通路在IRI过程中被激活，而肝脂肪变性则降低了激活水平。葛根素通过重新激活PI3K-AKT信号通路，明显保护脂肪肝免受IRI的影响。然而，PI3K-AKT 抑制剂 LY294002 削弱了葛根素的保护作用。总之，葛根素能通过激活PI3K-AKT信号通路显著保护脂肪肝免受IRI的影响。

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Puerarin protects the fatty liver from ischemia-reperfusion injury by regulating the PI3K/AKT signaling pathway.

The incidence of non-alcoholic fatty liver (NAFLD) remains high, and many NAFLD patients suffer from severe ischemia-reperfusion injury (IRI). Currently, no practical approach can be used to treat IRI. Puerarin plays a vital role in treating multiple diseases, such as NAFLD, stroke, diabetes, and high blood pressure. However, its role in the IRI of the fatty liver is still unclear. We aimed to explore whether puerarin could protect the fatty liver from IRI. C57BL/6J mice were fed with a high-fat diet (HFD) followed by ischemia reperfusion injury. We showed that hepatic IRI was more severe in the fatty liver compared with the normal liver, and puerarin could significantly protect the fatty liver against IRI and alleviate oxidative stress. The PI3K-AKT signaling pathway was activated during IRI, while liver steatosis decreased the level of activation. Puerarin significantly protected the fatty liver from IRI by reactivating the PI3K-AKT signaling pathway. However, LY294002, a PI3K-AKT inhibitor, attenuated the protective effect of puerarin. In conclusion, puerarin could significantly protect the fatty liver against IRI by activating the PI3K-AKT signaling pathway.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.