槲皮素通过调节血清元素和抑制大鼠前额叶皮质的铁突变,缓解由卵巢切除术和慢性不可预测的轻度应激诱发的围绝经期抑郁症

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biological Trace Element Research Pub Date : 2024-12-01 Epub Date: 2024-02-22 DOI:10.1007/s12011-024-04106-7
Dan Wang, Jing Wang, Ziran Yu, Ranqi Yao, Jingnan Zhang, Xiujuan Zhao
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引用次数: 0

摘要

本研究探讨了槲皮素对卵巢切除联合慢性不可预知轻度应激(OVX-CUMS)诱导的围绝经期抑郁模型大鼠血清元素变化的影响及其可能机制。根据蔗糖偏好试验结果,将大鼠随机分为四组:假组、OVX-CUMS组、OVX-CUMS + 17β-雌二醇组(17β-雌二醇:0.27 mg/kg.bw)和OVX-CUMS + 槲皮素组(槲皮素:50 mg/kg.bw)。实验结束后,收集大鼠血清和前额叶皮质。电感耦合等离子体质谱(ICP-MS)分析表明,与假组相比,OVX-CUMS 大鼠血清和前额叶皮质中钙(Ca)、镁(Mg)、硒(Se)、钴(Co)和锌(Zn)的含量降低,铁(Fe)和铜(Cu)的含量升高(p<0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quercetin Alleviates Perimenopausal Depression Induced by Ovariectomy Combined with Chronic Unpredictable Mild Stress Through Regulating Serum Elements and Inhibiting Ferroptosis in Prefrontal Cortex of Rats.

This study investigated the effects of quercetin on the alterations of serum elements in perimenopausal depression rat model induced by ovariectomy combined with chronic unpredictable mild stress (OVX-CUMS) and possible mechanisms. According to the results of the sucrose preference test, the rats were randomly assigned to four groups: sham, OVX-CUMS, OVX-CUMS + 17β-estradiol (17β-estradiol: 0.27 mg/kg.bw), and OVX-CUMS + Quercetin (Quercetin: 50 mg/kg.bw). At the end of experiment, serum and prefrontal cortex of rats were collected. The inductively coupled plasma mass spectrometry (ICP-MS) analysis showed that levels of calcium (Ca), magnesium (Mg), selenium (Se), cobalt (Co) and zinc (Zn) decreased, and levels of iron (Fe) and copper (Cu) increased in serum and prefrontal cortex of OVX-CUMS rats compared with sham group (p < 0.01). Meanwhile, the levels of the above elements in prefrontal cortex had correlation with behavioral characteristics in OVX-CUMS rats (p < 0.05 or p < 0.01). The abnormal elements in serum may cross blood-brain-barrier into the brain and induce oxidative stress, leading to ferroptosis. Furtherly, the expressions of ferroptosis-related protein including GPX4 and SLC7A11 were decreased in prefrontal cortex of OVX-CUMS rats (p < 0.01), which confirmed the above results. Quercetin treatment restored the above abnormal indicators (p < 0.05 or p < 0.01) induced by OVX-CUMS in rats. Our study suggested that quercetin regulated variation of elements in serum and prefrontal cortex, further inhibiting ferroptosis in prefrontal cortex through alleviating oxidative stress in OVX-CUMS rats.

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来源期刊
Biological Trace Element Research
Biological Trace Element Research 生物-内分泌学与代谢
CiteScore
8.70
自引率
10.30%
发文量
459
审稿时长
2 months
期刊介绍: Biological Trace Element Research provides a much-needed central forum for the emergent, interdisciplinary field of research on the biological, environmental, and biomedical roles of trace elements. Rather than confine itself to biochemistry, the journal emphasizes the integrative aspects of trace metal research in all appropriate fields, publishing human and animal nutritional studies devoted to the fundamental chemistry and biochemistry at issue as well as to the elucidation of the relevant aspects of preventive medicine, epidemiology, clinical chemistry, agriculture, endocrinology, animal science, pharmacology, microbiology, toxicology, virology, marine biology, sensory physiology, developmental biology, and related fields.
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