猫科动物和人类口腔鳞状细胞癌中 mPGES1 和 p16 的表达:一种比较肿瘤学方法。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
Veterinary and comparative oncology Pub Date : 2024-06-01 Epub Date: 2024-02-20 DOI:10.1111/vco.12967
Walaa Hamed Shaker Nasry, Kathleen Jones, Juan Carlos Rodriguez-Lecompte, Marvin Tesch, Chelsea K Martin
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引用次数: 0

摘要

癌症比较研究有助于我们确定在一个物种中的发现是否适用于另一个物种。猫科动物和人类口腔鳞状细胞癌(FOSCC 和 HOSCC)都是侵袭性肿瘤,其中有炎症和 p16 表达异常的报道。研究人员采用免疫组化方法测定了 42 个 HOSCC 和 45 个 FOSCC 样本中 p16 和微粒体前列腺素 E2 合成酶 1(mPGES1)的表达,这些样本中已知有环氧合酶 2(COX2)和分化簇 147(CD147)的表达。与邻近的基质和口腔上皮细胞相比,p16 高表达在 HOSCC 肿瘤细胞中更为常见(p .05)。在这两种肿瘤中,mPGES1 表达高的肿瘤和表达低的肿瘤在标记物表达上存在名义上的差异(p > 0.05),包括高 p16 表达在高 mPGES1 肿瘤中更常见,COX-2 阳性肿瘤在低 mPGES1 肿瘤中更常见。高 CD147 HOSCC 肿瘤在高 mPGES1 HOSCC 组中更为常见(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expression of mPGES1 and p16 in feline and human oral squamous cell carcinoma: A comparative oncology approach.

Comparative cancer studies help us determine if discoveries in one species apply to another. Feline and human oral squamous cell carcinoma (FOSCC and HOSCC) are invasive tumours in which inflammation and abnormal p16 expression are reported. Immunohistochemistry was used to determine the expression of p16 and microsomal prostaglandin E2 synthase 1 (mPGES1) in 42 HOSCC and 45 FOSCC samples with known expression of cyclooxygenase 2 (COX2) and cluster of differentiation 147 (CD147). High p16 expression was more common in HOSCC tumour cells compared to adjacent stroma and oral epithelium (p < .05), with a similar but statistically nonsignificant pattern in FOSCC. Interestingly, high mPGES1 expression in FOSCC was more common in the adjacent epithelium compared to the other compartments (p < .05). In HOSCC, mPGES1 was more similar between compartments but was numerically more common in the tumour compartment (p > .05). There were nominal (p > 0.05) differences in marker expression between high and low mPGES1 expressing tumours in both species, including high p16 observed more commonly in high mPGES1 tumours, and COX-2 positive tumours being more common in low mPGES1 tumours. High CD147 HOSCC tumours were more common in the high mPGES1 HOSCC group (p < .05). In the FOSCC cohort, where there was no statistical difference in CD147 expression between high and low mPGES1 tumours, there were numerically higher CD147 cases in the high mPGES1group. Different expression patterns in FOSCC and HOSCC could be related to different risk factors. For example, p16 is a marker of papillomavirus-driven HOSCC, but a causal relationship between papillomaviruses and FOSCC has yet to be definitively demonstrated. The significance of high P16 expression in the absence of papillomavirus infection deserves further study, and the relative contributions of COX2 and mPGES1 to tumour inflammation and progression should be explored. The findings reveal potential similarities in FOSCC and HOSCC biology, while also demonstrating differences that may relate to risk factors and pathogenesis that are unique to each species.

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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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