编码 mRNA 在单基因嗅觉受体选择中的非编码作用

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2024-03-01 Epub Date: 2024-02-19 DOI:10.1016/j.tins.2024.02.004

Yue Hao, Kang-Ying Qian, Qian Li

引用次数: 0

摘要

在最近的一项研究中，Pourmorady 及其同事发现了嗅觉受体（OR）编码 mRNA 在介导核结构和单一 OR 选择方面的非编码作用。嗅觉受体编码 mRNA 强化了主要的增强子枢纽，抑制了其他竞争者，促进了从多基因到单一嗅觉受体表达的过渡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

A noncoding role of coding mRNA in monogenic olfactory receptor choice.

In a recent study, Pourmorady and colleagues uncovered a noncoding role for olfactory receptor (OR)-coding mRNA in mediating nuclear architecture and singular OR choice. The OR mRNAs reinforce the prevailing enhancer hub and inhibit other competitors, facilitating transition from polygenic to singular OR expression.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.