自闭症谱系障碍合并多动症儿童大脑自发活动的改变。

IF 2.7 3区医学 Q2 PSYCHIATRY

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-02-20 DOI:10.1177/10870547241233207

Xinzhou Tang, Zenghui Ma, Kat SiuChing, Lingzi Xu, Qinyi Liu, Li Yang, Yufeng Wang, Qingjiu Cao, Xue Li, Jing Liu

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引用次数: 0

摘要

研究目的研究对象包括 17 名自闭症谱系障碍（ASD）儿童、21 名多动症（ADHD）儿童、30 名同时患有自闭症谱系障碍和多动症（ASD + ADHD）的儿童，以及 28 名发育正常的儿童（TD）：方法：测量低频波动振幅（ALFF）作为区域脑功能指数。还利用低频波动分析中确定的感兴趣区（ROI）对内在功能连接（iFC）进行了分析。统计分析通过单因素方差分析、高斯随机场（GRF）理论和事后配对比较进行：结果：与 TD 组相比，ASD + ADHD 组左侧额中回（MFG.L）的 ALFF 增加。在整体大脑功能方面，与ASD + ADHD组和TD组相比，ASD组在特定区域显示出连接性不足：结论：研究结果有助于理解ASD + ADHD的神经机制。

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Altered Intrinsic Brain Spontaneous Activities in Children With Autism Spectrum Disorder Comorbid ADHD.

Objective: The study involved 17 children with Autism Spectrum Disorder (ASD), 21 with ADHD, 30 with both (ASD + ADHD), and 28 typically developing children (TD).

Methods: The amplitude of low-frequency fluctuations (ALFF) was measured as a regional brain function index. Intrinsic functional connectivity (iFC) was also analyzed using the region of interest (ROI) identified in ALFF analysis. Statistical analysis was done via one-way ANCOVA, Gaussian random field (GRF) theory, and post-hoc pair-wise comparisons.

Results: The ASD + ADHD group showed increased ALFF in the left middle frontal gyrus (MFG.L) compared to the TD group. In terms of global brain function, the ASD group displayed underconnectivity in specific regions compared to the ASD + ADHD and TD groups.

Conclusion: The findings contribute to understanding the neural mechanisms underlying ASD + ADHD.

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来源期刊

Journal of Attention Disorders PSYCHIATRY-

CiteScore

7.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.