小儿队列中并发的乳糜泻和嗜酸性粒细胞食管炎：不仅仅是巧合。

IF 1 4区医学 Q3 PEDIATRICS

Clinical Pediatrics Pub Date : 2024-11-01 Epub Date: 2024-02-19 DOI:10.1177/00099228241232876

Arielle Bergman, Melanie Greifer, Jeremiah Levine

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引用次数: 0

摘要

乳糜泻（Celiac disease，CeD）和嗜酸性粒细胞食管炎（Eosinophilic esophagitis，EoE）是免疫介导的疾病，可能发生在同一患者身上。一家三甲医院开展了一项回顾性研究，以确定嗜酸性粒细胞性食管炎在患有糜烂性胃炎的儿科人群中的发病率，并比较患有这两种疾病的患者与仅患有糜烂性胃炎的患者的特征。在研究发现的 148 名 CeD 患者中，有 11 名患者同时患有 CeD 和咽喉炎（7.4%）。与仅患有 CeD 的患者相比，同时患有 CeD 和 EoE 的患者在确诊时的嗜酸性粒细胞绝对计数（每微升）更高（454.1 ± 122.7 vs 231.9 ± 19.4，P = .003）。总之，CeD 患者中患 EoE 的比例高于普通人群，这表明这两种疾病在病理生理学上可能存在重叠。外周嗜酸性粒细胞绝对计数升高可能有助于预测哪些 CeD 患者可能同时患有 EoE。

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Concurrent Celiac Disease and Eosinophilic Esophagitis in a Pediatric Cohort: More Than a Coincidence.

Celiac disease (CeD) and eosinophilic esophagitis (EoE) are immune-mediated disorders that can occur in the same patient. A retrospective study at a tertiary care hospital was conducted to determine the prevalence of EoE in a pediatric population with CeD and to compare characteristics of patients with both diseases to patients with CeD-only. Among the 148 patients with CeD identified in the study, 11 patients had both CeD and EoE (7.4%). Patients with both CeD and EoE had a higher absolute eosinophil count (per μL) at diagnosis compared to patients with CeD-only (454.1 ± 122.7 vs 231.9 ± 19.4, P = .003). In conclusion, there was a higher proportion of EoE in patients with CeD than would be expected in the general population, suggesting a potential pathophysiological overlap between the 2 diseases. An elevated peripheral absolute eosinophil count may help predict which patients with CeD may additionally have EoE.

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来源期刊

Clinical Pediatrics 医学-小儿科

CiteScore

2.10

自引率

6.20%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical Pediatrics (CLP) a peer-reviewed monthly journal, is a must read for the busy pediatrician. CLP contains state-of-the-art, accurate, concise and down-to earth information on practical, everyday child care topics whether they are clinical, scientific, behavioral, educational, or ethical.