泪液引流系统原发性乳头状瘤的长期疗效

IF 1.2 4区 医学 Q3 OPHTHALMOLOGY
Kaveh Vahdani, Geoffrey E Rose
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引用次数: 0

摘要

目的:报告泪道引流系统原发性良性乳头状瘤手术后的长期疗效:方法:对1984年至2021年间首次发现的原发性泪液引流系统乳头状瘤患者进行回顾性研究,但不包括鼻窦源性或恶性组织学病变。根据肿瘤组织学(鳞状细胞、过渡细胞和混合细胞)和生长模式(外生性、内生性或混合性)对患者进行分类:30 名患者(18 名女性;60%)的平均年龄为 46.1 岁(12-79 岁)。在平均 10.4 年的随访中,30% 的患者复发,不同生长模式的复发率略有不同:外生性肿瘤为 25%,内生性和混合型肿瘤为 40%(P = 0.431)。总体5年无复发生存率为67%(标准误差为±9%),外生性病变的无复发生存率(75%±10%)略高于内生性肿瘤的48%(±19%)(p = 0.370)。没有观察到恶性转化的病例,复发时的肿瘤类型与最初的诊断相符:结论:泪腺引流系统原发性良性乳头状瘤的长期复发率约为三分之一,内生性生长模式的复发率更高。这项研究强调了长期监测复发的重要性,尤其是内生型和混合生长型肿瘤,以及恶性转化的可能性。研究结果支持采用内窥镜手术切除术或激光热消融术治疗泪囊鼻腔造口术后复发的泪道引流系统乳头状瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-Term Outcome for Primary Papillomas of the Lacrimal Drainage System.

Purpose: To report long-term outcomes after surgery for primary benign papillomas of the lacrimal drainage system.

Methods: Retrospective review of patients with primary lacrimal drainage system papillomas, first seen between 1984 and 2021, but excluding lesions with sino-nasal origin or malignant histology. Patients were categorized by tumor histology (squamous, transitional, and mixed cell) and growth pattern (exophytic, endophytic, or mixed).

Results: Thirty patients (18 female; 60%) presented at a mean age of 46.1 years (12-79 years). Over an average follow-up of 10.4 years, 30% of patients experienced recurrence, with rates differing slightly by growth pattern: 25% for exophytic tumors and 40% for endophytic and mixed-pattern tumors ( p = 0.431). The overall 5-year recurrence-free survival was 67% (± 9% standard error), this being slightly higher for exophytic lesions (75% ± 10%) as compared to 48% (± 19%) for tumors with an endophytic component ( p = 0.370). No cases of malignant transformation were observed, and the tumor type at recurrence matched the initial diagnosis.

Conclusion: Primary benign papillomas of the lacrimal drainage system have a long-term recurrence rate of about one-third, with a higher frequency in those exhibiting an endophytic growth pattern. The study highlights the importance of prolonged surveillance for recurrence, especially for endophytic and mixed growth pattern tumors, and for the potential to undergo malignant transformation. The results support the effectiveness of endoscopic surgical excision or laser thermos-ablation in managing recurrent lacrimal drainage system papillomas after dacryocystorhinostomy.

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来源期刊
CiteScore
2.50
自引率
10.00%
发文量
322
审稿时长
3-8 weeks
期刊介绍: Ophthalmic Plastic and Reconstructive Surgery features original articles and reviews on topics such as ptosis, eyelid reconstruction, orbital diagnosis and surgery, lacrimal problems, and eyelid malposition. Update reports on diagnostic techniques, surgical equipment and instrumentation, and medical therapies are included, as well as detailed analyses of recent research findings and their clinical applications.
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