通过单细胞基因组学揭示宿主与病原体相互作用的复杂性。

IF 2.6 4区医学 Q3 IMMUNOLOGY

Microbes and Infection Pub Date : 2024-09-01 DOI:10.1016/j.micinf.2024.105313

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引用次数: 0

摘要

单细胞基因组学为研究人员提供了以以前无法达到的分辨率评估宿主与病原体相互作用的工具。转录组分析、表观基因组分析和免疫剖析技术使我们能够更好地理解宿主反应和传染源的异质性。在此，我们将重点介绍技术进步和数据分析工作流程，这些技术和流程可加深我们对单细胞水平上宿主与病原体相互作用的理解。我们回顾了利用这些工具更好地了解病毒、细菌和寄生虫病等各种传染病中宿主-病原体动态的各种研究。最后，我们将讨论单细胞基因组学如何促进我们对宿主-病原体相互作用的理解。

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Unraveling the intricacies of host-pathogen interaction through single-cell genomics

Single-cell genomics provide researchers with tools to assess host-pathogen interactions at a resolution previously inaccessible. Transcriptome analysis, epigenome analysis, and immune profiling techniques allow for a better comprehension of the heterogeneity underlying both the host response and infectious agents. Here, we highlight technological advancements and data analysis workflows that increase our understanding of host-pathogen interactions at the single-cell level. We review various studies that have used these tools to better understand host-pathogen dynamics in a variety of infectious disease contexts, including viral, bacterial, and parasitic diseases. We conclude by discussing how single-cell genomics can advance our understanding of host-pathogen interactions.

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来源期刊

Microbes and Infection 医学-病毒学

CiteScore

12.60

自引率

1.70%

发文量

审稿时长

40 days

期刊介绍： Microbes and Infection publishes 10 peer-reviewed issues per year in all fields of infection and immunity, covering the different levels of host-microbe interactions, and in particular: the molecular biology and cell biology of the crosstalk between hosts (human and model organisms) and microbes (viruses, bacteria, parasites and fungi), including molecular virulence and evasion mechanisms. the immune response to infection, including pathogenesis and host susceptibility. emerging human infectious diseases. systems immunology. molecular epidemiology/genetics of host pathogen interactions. microbiota and host "interactions". vaccine development, including novel strategies and adjuvants. Clinical studies, accounts of clinical trials and biomarker studies in infectious diseases are within the scope of the journal. Microbes and Infection publishes articles on human pathogens or pathogens of model systems. However, articles on other microbes can be published if they contribute to our understanding of basic mechanisms of host-pathogen interactions. Purely descriptive and preliminary studies are discouraged.