{"title":"预测霍奇金淋巴瘤预后的脂肪组织指数","authors":"Demircan Özbalcı , Mehmet Erdoğan , Emine Güçhan Alanoğlu , Sevim Süreyya Şengül , Kamuran Yüceer , Hande Nur Eroğlu , Samet Yağcı","doi":"10.1016/j.leukres.2024.107457","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction background</h3><p>This study evaluated the impact of adipose tissue indices on prognosis of HL.</p></div><div><h3>Methods</h3><p>Fifty-five patients with newly diagnosed Hodgkin Lymphoma were evaluated retrospectively for association with adipose tissue indices (total abdominal tissue volume, radiodensity, subcutaneous and visceral adipose tissue SUVmax value and prognostic factors for Hodgkin Lymphoma such as IPS-3, IPS-7, stage, sedimentation, progression free and overall survival.</p></div><div><h3>Results</h3><p>For IPS-3, SAT SUVmax and TAAT radiodensity were significantly increased in high-risk patients (2and 3) compared to group 0 and 1. For IPS-7, total abdominal adipose volume was significantly decreased in high-risk patients, SAT SUVmax significantly increased in high-risk patients and decreased in low-risk patients. In addition, SAT SUVmax was significantly increased in patients with high sedimentation rate, with B symptoms and who passed away during follow-up. SAT SUVmax showed moderate positive correlation with sedimentation, IPS-3, IPS-7, and stage. In addition, it was observed that TAAT radiodensity and SAT SUVmax were significantly better for determining prognosis than other adipose tissue indices. Roc analysis showed that the diagnostic value of all adipose tissue indices in predicting IPS-3 and IPS-7 prognoses were statistically significant.</p></div><div><h3>Conclusion</h3><p>SAT SUVmax and TAAT radiodensity were two new and independent markers with diagnostic value in predicting prognosis.</p></div>","PeriodicalId":18051,"journal":{"name":"Leukemia research","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Adipose tissue indices predict prognosis in hodgkin lymphoma\",\"authors\":\"Demircan Özbalcı , Mehmet Erdoğan , Emine Güçhan Alanoğlu , Sevim Süreyya Şengül , Kamuran Yüceer , Hande Nur Eroğlu , Samet Yağcı\",\"doi\":\"10.1016/j.leukres.2024.107457\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction background</h3><p>This study evaluated the impact of adipose tissue indices on prognosis of HL.</p></div><div><h3>Methods</h3><p>Fifty-five patients with newly diagnosed Hodgkin Lymphoma were evaluated retrospectively for association with adipose tissue indices (total abdominal tissue volume, radiodensity, subcutaneous and visceral adipose tissue SUVmax value and prognostic factors for Hodgkin Lymphoma such as IPS-3, IPS-7, stage, sedimentation, progression free and overall survival.</p></div><div><h3>Results</h3><p>For IPS-3, SAT SUVmax and TAAT radiodensity were significantly increased in high-risk patients (2and 3) compared to group 0 and 1. For IPS-7, total abdominal adipose volume was significantly decreased in high-risk patients, SAT SUVmax significantly increased in high-risk patients and decreased in low-risk patients. In addition, SAT SUVmax was significantly increased in patients with high sedimentation rate, with B symptoms and who passed away during follow-up. SAT SUVmax showed moderate positive correlation with sedimentation, IPS-3, IPS-7, and stage. In addition, it was observed that TAAT radiodensity and SAT SUVmax were significantly better for determining prognosis than other adipose tissue indices. Roc analysis showed that the diagnostic value of all adipose tissue indices in predicting IPS-3 and IPS-7 prognoses were statistically significant.</p></div><div><h3>Conclusion</h3><p>SAT SUVmax and TAAT radiodensity were two new and independent markers with diagnostic value in predicting prognosis.</p></div>\",\"PeriodicalId\":18051,\"journal\":{\"name\":\"Leukemia research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2024-02-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Leukemia research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0145212624000237\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Leukemia research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0145212624000237","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
方法回顾性评估55例新诊断的霍奇金淋巴瘤患者的脂肪组织指数（腹部组织总体积、放射性密度、皮下和内脏脂肪组织SUVmax值）与霍奇金淋巴瘤预后因素（如IPS-3、IPS-7、分期、血沉、无进展生存期和总生存期）的相关性。结果 在IPS-3中，与0组和1组相比，高危患者（2组和3组）的SAT SUVmax和TAAT放射密度明显增加。 在IPS-7中，高危患者的腹部脂肪总量明显减少，SAT SUVmax在高危患者中明显增加，在低危患者中减少。此外，血沉高、有 B 型症状和在随访期间去世的患者的 SAT SUVmax 明显增高。SAT SUVmax 与血沉、IPS-3、IPS-7 和分期呈中度正相关。此外，还观察到 TAAT 放射性密度和 SAT SUVmax 在判断预后方面明显优于其他脂肪组织指数。Roc分析表明，所有脂肪组织指数在预测IPS-3和IPS-7预后方面的诊断价值均具有统计学意义。
Adipose tissue indices predict prognosis in hodgkin lymphoma
Introduction background
This study evaluated the impact of adipose tissue indices on prognosis of HL.
Methods
Fifty-five patients with newly diagnosed Hodgkin Lymphoma were evaluated retrospectively for association with adipose tissue indices (total abdominal tissue volume, radiodensity, subcutaneous and visceral adipose tissue SUVmax value and prognostic factors for Hodgkin Lymphoma such as IPS-3, IPS-7, stage, sedimentation, progression free and overall survival.
Results
For IPS-3, SAT SUVmax and TAAT radiodensity were significantly increased in high-risk patients (2and 3) compared to group 0 and 1. For IPS-7, total abdominal adipose volume was significantly decreased in high-risk patients, SAT SUVmax significantly increased in high-risk patients and decreased in low-risk patients. In addition, SAT SUVmax was significantly increased in patients with high sedimentation rate, with B symptoms and who passed away during follow-up. SAT SUVmax showed moderate positive correlation with sedimentation, IPS-3, IPS-7, and stage. In addition, it was observed that TAAT radiodensity and SAT SUVmax were significantly better for determining prognosis than other adipose tissue indices. Roc analysis showed that the diagnostic value of all adipose tissue indices in predicting IPS-3 and IPS-7 prognoses were statistically significant.
Conclusion
SAT SUVmax and TAAT radiodensity were two new and independent markers with diagnostic value in predicting prognosis.
期刊介绍：
Leukemia Research an international journal which brings comprehensive and current information to all health care professionals involved in basic and applied clinical research in hematological malignancies. The editors encourage the submission of articles relevant to hematological malignancies. The Journal scope includes reporting studies of cellular and molecular biology, genetics, immunology, epidemiology, clinical evaluation, and therapy of these diseases.
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