持续服用庆大霉素导致的致命后果：一份病例报告

Q4 Medicine

Adverse Drug Reaction Bulletin Pub Date : 2024-02-01 DOI:10.1097/fad.0000000000000072

Gerard Ronda-Roca, A. Sancho-López, Belén Ruiz-Antorán, Esther Montero-Hernández, Alicia San Martin-Espinosa

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引用次数: 0

摘要

庆大霉素是一种氨基糖苷类抗生素，主要通过抑制革兰氏阴性细菌的核糖体来发挥杀菌作用。它具有浓度依赖性药效学效应，因此最好采用延长间隔剂量。因此，总剂量通常为每天一次，而不是每天分两次或三次服用。这种剂量的疗效极佳，因为可以获得适当的峰值浓度，同时还能降低肾毒性的风险，因为这与庆大霉素的残留浓度有关。欧洲药品管理局的《产品特征摘要》指出，使用庆大霉素治疗的患者中，1/10 到 1/100 的患者可能会出现肾功能恶化。我们为您介绍一位 92 岁的女性患者，她体重 39 公斤，有慢性肾病（CKD）和慢性心力衰竭病史，因处方错误使用庆大霉素而导致致命的肾毒性。

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A fatal outcome due to a continuous dosage of gentamicin: a case report

Gentamicin, an aminoglycoside antibiotic, exerts its bactericidal effect primarily through the inhibition of ribosomes in Gram-negative bacteria. It has a concentration-dependent pharmacodynamic effect, making an extended-interval dosage preferable. The total dose is, therefore, usually administered as a single daily dose instead of divided portions two or three times a day. This dosage has shown an excellent efficacy because an appropriate peak concentration is obtained, whilst the risk of nephrotoxicity is reduced as this is correlated with the residual concentration of gentamicin. In the European Medicines Agencies Summary of Products Characteristics, it is stated that deterioration of kidney function could be expected in 1/10 to 1/100 patients treated with gentamicin. We present a 92-year-old female patient with a weight of 39 kg, history of chronic kidney disease (CKD) and chronic heart failure that presented a fatal nephrotoxicity due to a prescription error of gentamicin.

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来源期刊

Adverse Drug Reaction Bulletin Medicine-Pharmacology (medical)

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： For over 40 years, Adverse Drug Reaction Bulletin has provided comprehensive coverage in the field of adverse drug reactions. Each issue contains an invited article on a topic of current interest, dealing with specific conditions from drug-induced lung disorders to drug-induced sexual dysfunction, or types of drugs from lipid-lowering agents to poisons antidotes. This bimonthly journal"s articles are timely, succinct and fully referenced