植物黄酮类药物对妇科癌症的抗癌潜力

Kavita Sangwan, Parveen Kumar Goyal
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引用次数: 0

摘要

据科学报道,黄酮类化合物是中草药的主要生物活性成分之一,具有抗癌、免疫调节、神经保护、心脏保护、抗氧化等多种治疗潜力。本手稿揭示了传统草药黄酮类化合物在妇科癌症中的抗癌潜力、本手稿旨在深入汇编草本黄酮类化合物在妇科癌症中的科学证据,以及针对妇科癌症的靶向给药系统。文章中的内容和数据已通过机构图书馆和在线数据库资源(可在公共领域获取)进行了审查,如 PubMed、Science-Direct、Web of Science、美国医药科学家协会、Google Scholar、Hinari、SciFinder、Research Gate 等。体外和体内实验证明,黄酮类化合物对妇科癌症,尤其是宫颈癌、卵巢癌和子宫内膜癌具有显著的抗癌潜力。据体外实验报告,靶向给药系统提高了黄酮类化合物的抗癌效果。植物黄酮类化合物可通过诱导细胞凋亡、细胞周期停滞和活性氧生成来预防妇科癌症。关于类黄酮的给药系统还有待进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-cancer Potential of Phytoflavonoidal Drugs against Gynecological Cancer
Flavonoids, one of the major bioactive constituents of herbal drugs, have been scientifically reported to possess diverse therapeutic potentials such as anticancer, immunomodulatory, neuroprotective, cardioprotective, antioxidant, etc. This manuscript enlightens the anticancer potential of traditional herbal flavonoids in gynecological cancer i.e., is one of the major life-threats in women. This manuscript is aimed at an insightful compilation of scientific substantiations of herbal flavonoids in gynecological cancer along with targeted drug delivery systems for the same. The contents and data represented in the article have been reviewed using institutional libraries and online database resources (available in the public domain) such as PubMed, Science-Direct, Web of Science, American Association of Pharmaceutical Scientists, Google Scholar, Hinari, SciFinder, Research Gate, etc. Flavonoids are natural compounds and have potential against cervical, ovarian, and endometrial cancer. In-vitro and in-vivo experiments have demonstrated the significant potential of flavonoids in gynecological cancer, especially cervical, ovarian, and endometrial cancer. It was reported from in-vitro experimentations that targeted drug delivery system improves the anticancer effect of flavonoids. Phytoflavonoids have the potential to prevent gynecological cancer by induction of apoptosis cell cycle arrest and reactive oxygen species generation. Further studies on the drug delivery system of flavonoids are warranted.
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