CBC衍生物与covid-19患者生化预后指标的相关性研究

Roshna Vijay
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摘要

:SARS-CoV2 感染会诱发人类的炎症反应和急性肺损伤。感染会引起患者某些血液学和生化指标的变化。本研究旨在分析 COVID-19 感染者的血细胞计数衍生物与生化预后指标之间的相关性:共选取 80 人,其中 50 人为 COVID-19 阳性患者,30 人为 COVID-19 RT-PCR 测试阴性患者。采集的血液送至 RDW 的 NLR,在 Beckman Coulter DxH 800 中进行化验。血清 CRP 采用免疫比浊法估算,铁蛋白采用 CLIA 法估算。收集的血浆通过 CLIA 方法估算 D-DIMER。采用非配对 T 检验和皮尔逊相关性检验(IBM SPSS 22.0)。 结果表明:NLR 水平升高(p 值<0.001)、RDW 水平升高(p 值<0.001)、铁蛋白水平升高(p 值<0.001)、D-DIMER 水平升高(p 值<0.001)、CRP 水平升高(p 值<0.001),而 LHD 和 RSF 等一些研究参数则明显下降。在本研究中,NLR 与 CRP 呈正相关(r 值=0.5,p 值<0.001),NLR 与 D-DIMER 呈正相关(r 值=0.3,p 值<0.05),RDW 与 CRP 呈正相关(r 值=,0.3,p 值<0.05),RDW 与铁蛋白呈负相关(r 值=-0.439,P值<0.001),LHD与铁蛋白负相关(r值=-0.316,P值=<0.05),MAF与D-二聚体负相关(r值=-0.244<0.05),MSCV与CRP正相关(r值=0.336,P值=<0.05):covid-19感染期间产生的细胞因子风暴会导致中性粒细胞增多、淋巴细胞减少、CRP生成,并引起促凝血剂和二聚体升高。RDW和CRP呈正相关,它们在炎症时升高。回顾性研究有一定的局限性,因此未来的研究将揭示更多信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation study of CBC derivatives and biochemical prognostic marker in covid-19 patients
: SARS-CoV2 infection induces inflammatory responses and acute lung injury in human beings. Infection causes certain haematological and biochemical changes in patients. This study aimed analyze the correlation between CBC derivatives and biochemical prognostic marker in COVID-19.: Total 80 individuals selected, 50 COVID-19 positive patients and 30 subjects negative for COVID-19 RT-PCR test. Blood collected was sent to NLR, RDW, assayed in Beckman Coulter DxH 800. Serum CRP estimated by Immuno-turbidimetric method, ferritin by CLIA. Plasma collected estimate for D-DIMER by CLIA. Unpaired T test & Pearson correlation (IBM SPSS 22.0) were used. : Elevated levels of NLR (p value <0.001), RDW (p value <0.001), FERRITIN (p value <0.001), D-D-DIMER (p value <0.001), CRP (p value <0.001) some research parameters like LHD and RSF show significant decrease. In current study the NLR positively correlate to CRP (r value=0.5, p value <0.001), NLR positively correlate to D-DIMER (r value=0.3, p value<0.05), RDW positively correlated to CRP (r value=, 0.3, p value <0.05), RDW negatively correlated to ferritin (r value=-0.439, p value <0.001)LHD negatively correlated ferritin (r value=-0.316, p value=<0.05), MAF negatively correlated to D-dimer (r value=-0.244 <0.05), MSCV positively correlated with CRP (r value=0.336, p value= <0.05).: The cytokine storm produced during covid-19 infection which inturn develop neutrophilia and lymphopenia, CRP production and also cause elevation of procoagulants &D-dimer. RDW and CRP are positively correlated they are elevated during inflammatory conditions.RDW and FERRITIN show negative correlation. Retrospective study have some limitation so future studies will reveal more information.
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