乳腺癌患者接受蒽环类药物治疗后冠状动脉流速储备下降

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Christopher Yu MBBS , Prajith Jeyaprakash MBBS , Koya Ozawa MD, PhD , Tomoko Negishi MD , Dhanusha Sabanathan MBBS, PhD , John Park MBBS, PhD , Jennifer Man MBBS, PhD , Anuradha Vasista MBBS, PhD , Faraz Pathan MBBS, PhD , Kazuaki Negishi MD, PhD, MSc
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引用次数: 0

摘要

蒽环类疗法(ANT)与癌症治疗相关的心脏功能障碍有关。冠状动脉血流速度储备(CFVR)在非癌症人群中显示出了预后效用,但在心脏病学环境中尚未获得相关数据。我们研究了 ANT 对乳腺癌患者冠状动脉血流速度储备的急性影响。共有 12 名女性乳腺癌患者接受了 ANT 前和 ANT 后的 CFVR 评估。CFVR出现了明显下降(基线:2.66 ± 0.41 vs ANT后:2.47 ± 0.37,P = 0.016)。这项前瞻性研究首次发现了 ANT 相关的人体冠状动脉生理变化。要确定其临床意义,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Coronary Flow Velocity Reserve Declines After Anthracycline Therapy in Breast Cancer Patients

Coronary Flow Velocity Reserve Declines After Anthracycline Therapy in Breast Cancer Patients

Anthracycline therapy (ANT) is associated with cancer therapy-related cardiac dysfunction. Coronary flow velocity reserve (CFVR) has shown prognostic utility in non-cancer cohorts, but no data have been obtained in a cardio-oncology setting. We investigated the acute effect of ANT on CFVR in breast cancer patients. A total of 12 female breast cancer patients undergoing ANT had pre- and post-ANT CFVR assessment. A significant decline in CFVR occurred (baseline: 2.66 ± 0.41 vs post-ANT: 2.47 ± 0.37, P = 0.016). This prospective study is the first to identify ANT-related coronary physiology changes in humans. Further studies are required to determine their clinical significance.

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来源期刊
CJC Open
CJC Open Medicine-Cardiology and Cardiovascular Medicine
CiteScore
3.30
自引率
0.00%
发文量
143
审稿时长
60 days
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