D-allose 对新生大鼠心肌细胞 ATP 生成和细胞活力的影响

IF 3 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of pharmacological sciences Pub Date : 2024-02-15 DOI:10.1016/j.jphs.2024.02.009

Xi Chen , Asadur Rahman , Steeve Akumwami , Asahiro Morishita , Kento Kitada , Yasumasa Ikeda , Masafumi Funamoto , Akira Nishiyama

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引用次数: 0

摘要

2-Deoxy-d-glucose (2DG) 通过抑制糖酵解产生抗癌作用，但可能会增加心律失常的风险。罕见的单糖 d-阿洛糖也具有抗癌作用，但其对心脏的影响尚不清楚。我们研究了 d-allose 对新生大鼠心肌细胞产生三磷酸腺苷（ATP）的影响。我们发现，25 毫摩尔 d-阿洛糖选择性地减少了糖酵解 ATP，但对线粒体 ATP 的影响很小，而 1 毫摩尔 2DG 则强烈地抑制了糖酵解 ATP 和线粒体 ATP。此外，与 2DG 相比，d-阿洛糖对细胞活力的影响较小，细胞毒性也较弱；两种化合物都不会导致细胞凋亡。因此，d-阿洛糖选择性地减少了糖酵解 ATP 的产生，而对心肌细胞没有明显影响。

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Effects of D-allose on ATP production and cell viability in neonatal rat cardiomyocytes

2-Deoxy-d-glucose (2DG) induces anticancer effects through glycolytic inhibition but it may raise the risk of arrhythmia. The rare monosaccharide d-allose also has anticancer properties, but its cardiac effects are unknown. We examined the effects of d-allose on adenosine triphosphate (ATP) production in neonatal rat cardiomyocytes. We showed that 25 mM d-allose selectively reduced glycolytic ATP, but had minimal impact on mitochondrial ATP, while 1 mM 2DG strongly inhibited both. Furthermore, d-allose had less impact on cell viability and was less cytotoxic than 2DG; neither compound caused apoptosis. Thus, d-allose selectively diminished glycolytic ATP production with no apparent effects on cardiomyocytes.

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来源期刊

Journal of pharmacological sciences 医学-药学

CiteScore

6.20

自引率

2.90%

发文量

104

审稿时长

31 days

期刊介绍： Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.