SOX30 在人类癌症中的多重作用和功能

Cancer Innovation Pub Date : 2024-02-04 DOI:10.1002/cai2.107
Na Sun, Cheng Wang, Pingping Gao, Rui Wang, Yi Zhang, Xiaowei Qi
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引用次数: 0

摘要

SRY-盒转录因子30(SOX30)参与肺癌中肿瘤细胞的凋亡。体细胞SOX30突变的发生、SOX30在正常组织和癌症组织中的表达特征、SOX30与免疫细胞和免疫相关基因的相关性以及SOX30在各种癌症中的临床意义激发了人们对SOX30作为潜在癌症生物标志物的兴趣。SOX30 会影响特定癌症类型的药物敏感性和肿瘤免疫。在这篇综述中,我们结合生物信息学证据和文献综述,全面总结了有关 SOX30 在癌症中作用的最新研究。我们总结了有关 SOX30 在癌症中的体细胞突变、试验、转录组分析、临床信息以及 SOX30 介导的恶性表型调控等方面的最新研究。此外,我们还报告了不同癌症类型中 SOX30 mRNA 表达水平的诊断价值。这篇关于 SOX30 在癌症进展中的作用的综述可为 SOX30 在癌症中的可能研究方向提供见解,并为指导未来的研究提供理论依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Multifaceted roles and functions of SOX30 in human cancer

Multifaceted roles and functions of SOX30 in human cancer

SRY-box transcription factor 30 (SOX30) participates in tumor cell apoptosis in lung cancer. The occurrence of somatic SOX30 mutations, the expression signature of SOX30 in normal and cancer tissues, the correlation of SOX30 with immune cells and immune-related genes, and the clinical significance of SOX30 in various cancers have stimulated interest in SOX30 as a potential cancer biomarker. SOX30 influences drug sensitivity and tumor immunity in specific cancer types. In this review, we have comprehensively summarized the latest research on the role of SOX30 in cancer by combining bioinformatics evidence and a literature review. We summarize recent research on SOX30 in cancer regarding somatic mutations, trials, transcriptome analysis, clinical information, and SOX30-mediated regulation of malignant phenotypes. Additionally, we report on the diagnostic value of SOX30 mRNA expression levels across different cancer types. This review on the role of SOX30 in cancer progression may provide insights into possible research directions for SOX30 in cancer and a theoretical basis for guiding future studies.

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