prednumstine、大剂量亚叶酸和5-氟尿嘧啶作为晚期乳腺癌补救性化疗前的Premarin灌注。

Chemioterapia : international journal of the Mediterranean Society of Chemotherapy Pub Date : 1988-04-01

G Marini, E Simoncini, P Marpicati, E Montini, V Ferrari, G Arcangeli, A Zaniboni

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引用次数: 0

摘要

采用普雷马林、泼尼莫司汀、大剂量亚叶酸和5-氟尿嘧啶联合治疗30例晚期乳腺癌患者。在30例可评估患者中，9例(30%)获得客观缓解(中位持续时间:9个月)。局限性毒性为口腔黏膜炎，骨髓抑制较轻。尽管作为补救方案具有相当大的活性，但这些结果似乎并不比本研究所单独使用大剂量亚叶酸和5-氟尿嘧啶所取得的结果更好。

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Premarin priming before prednimustine, high-dose folinic acid and 5-fluorouracil as salvage chemotherapy for advanced breast cancer.

Thirty patients with advanced and mainly pretreated breast cancer were treated with a combination of premarin, prednimustine, high-dose folinic acid and 5-fluorouracil. Among the 30 evaluable patients, 9 (30%) achieved an objective response (median duration: 9 months). Oral mucositis was the limiting toxicity, while myelosuppression was quite mild. In spite of considerable activity as salvage regimen, these results do not seem better than those achieved in our Institute with high-dose folinic acid and 5-fluorouracil alone.

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Chemioterapia : international journal of the Mediterranean Society of Chemotherapy

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