糖尿病患者血清孤儿素的围手术期变化及其与交感神经系统的关系

IF 2.5 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Lin-Zhong Zhang , Meng-Li Xie , Jing Li , Yu-Zhang Liang , Si-Kun Chen , Yi Han
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引用次数: 0

摘要

糖尿病患者在围手术期发生心血管事件与交感神经的激活有关。基础研究表明,糖尿病神经病变大鼠的血清痛觉素/表皮素 FQ(N/OFQ)水平升高,N/OFQ 可减少去甲肾上腺素(NE)的释放。我们假设 N/OFQ 会影响糖尿病患者心肌围手术期的交感神经系统。66 例单侧膝关节置换术患者被分为糖尿病组(D 组)和非糖尿病组(N 组)。分别测量麻醉前 30 分钟(T0)、术后 1 小时(T1)、术后 24 小时(T2)的血糖、血清 NE、N/OFQ 浓度以及 T0 和 T2 的心肌肌钙蛋白 I(cTnI)浓度。与 N 组相比,D 组在 T0 时的血糖、N/OFQ 和 cTnI 浓度较高,NE 较低(P < 0.05)。T1时,D组血糖、N/OFQ和NE浓度升高,N组仅血糖升高(P <0.05)。D组血清N/OFQ从T0到T1与血糖、NE浓度从T0到T1以及cTnI从T0到T2的变化趋势相关(r = 0.386,P = 0.027;r = 0.350,P = 0.046;r = 0.363,P = 0.038)。结果表明,糖尿病患者术前血清N/OFQ浓度升高,术中N/OFQ浓度升高与NE和cTnI浓度升高有关,围术期N/OFQ可能通过交感神经系统介导心肌损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Perioperative changes of serum orphanin in diabetic patients and its relationship with sympathetic nervous system

Perioperative changes of serum orphanin in diabetic patients and its relationship with sympathetic nervous system

The occurrence of cardiovascular events in diabetic patients during the perioperative period is related to the activation of sympathetic nerves. Basic research shows that serum nociceptin/orphanin FQ (N/OFQ) levels in diabetic neuropathy rats increased, and N/OFQ reduces the release of norepinephrine (NE). We hypothesize that N/OFQ will affect the sympathetic nervous system during perioperative myocardium of diabetic patients. 66 patients with unilateral knee arthroplasty were divided into diabetes group (D group) and non-diabetes group (N group). Measured blood glucose, serum NE, N/OFQ concentrations at the 30 min before anesthesia (T0), 1 h after surgery (T1), 24 h after surgery (T2) and the cardiac troponinI (cTnI) concentration at T0 and T2. Compared with N group, the concentration of blood glucose, N/OFQ and cTnI in D group was higher and the NE was lower at T0 (P < 0.05). At T1, the blood glucose, N/OFQ, NE concentrations of D group increased, only the blood glucose increased in N group (P < 0.05). Serum N/OFQ of D group from T0 to T1 was correlated with the change trend of blood glucose, NE concentration from T0 to T1 and cTnI from T0 to T2(r = 0.386, P = 0.027; r = 0.350, P = 0.046; r = 0.363, P = 0.038). The outcomes demonstrated that the preoperative serum N/OFQ concentration in diabetic patients was increased, and the increase in N/OFQ concentration during the operation was related to the increase in NE and cTnI concentrations, perioperative N/OFQ may mediate myocardial injury through sympathetic nervous system.

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来源期刊
Neuropeptides
Neuropeptides 医学-内分泌学与代谢
CiteScore
5.40
自引率
6.90%
发文量
55
审稿时长
>12 weeks
期刊介绍: The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.
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