二烷基芳基膦脲配体的设计与合成及其在钯催化交叉偶联反应中的应用

IF 1.5 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Helvetica Chimica Acta Pub Date : 2024-02-09 DOI:10.1002/hlca.202300244

Lupita S. Aguirre, Levi T. Litwiller, Alexis N. Lugo, Andy A. Thomas

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引用次数: 0

摘要

我们在本文中介绍了一种含有路易斯碱性脲亚基的新型二烷基膦配体的合成和设计。配体的合成包括六个线性步骤，并通过发现一种新的 N-N 烷基迁移反应得以实现。这一系列新的二烷基膦脲配体被应用于普通的钯催化交叉偶联反应中，以中等至高产率形成碳-碳和碳-氮键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Design and Synthesis of Dialkylarylphosphine Urea Ligands and their Application in Palladium-Catalyzed Cross-Coupling Reactions

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Design and Synthesis of Dialkylarylphosphine Urea Ligands and their Application in Palladium-Catalyzed Cross-Coupling Reactions

We describe herein the design and synthesis of a new class of dialkylarylphosphine ligands incorporating a Lewis-basic urea subunit. The ligand synthesis consisted of six linear steps and was enabled by the discovery of a new N-to-N alkyl migration reaction. This new series of dialkylarylphosphine urea ligands were applied in common palladium-catalyzed cross-coupling reactions for the formation of carbon-carbon and carbon-nitrogen bonds in moderate to high yields.

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来源期刊

Helvetica Chimica Acta 化学-化学综合

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

2.3 months

期刊介绍： Helvetica Chimica Acta, founded by the Swiss Chemical Society in 1917, is a monthly multidisciplinary journal dedicated to the dissemination of knowledge in all disciplines of chemistry (organic, inorganic, physical, technical, theoretical and analytical chemistry) as well as research at the interface with other sciences, where molecular aspects are key to the findings. Helvetica Chimica Acta is committed to the publication of original, high quality papers at the frontier of scientific research. All contributions will be peer reviewed with the highest possible standards and published within 3 months of receipt, with no restriction on the length of the papers and in full color.