从 Immunoscore 中提取的 KIF26B 和 CREB3L1 可抑制卵巢癌的进展

IF 3.5 3区医学 Q2 IMMUNOLOGY

Journal of Immunology Research Pub Date : 2024-02-13 DOI:10.1155/2024/4817924

Shanshan Cong, Yao Fu, Xibo Zhao, Qiuyan Guo, Tian Liang, Di Wu, Jing Wang, Guangmei Zhang

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引用次数: 0

摘要

背景。卵巢癌（OV）是女性生殖系统恶性肿瘤中发病率和致死率较高的一种。对卵巢癌发病机制和治疗靶点的研究仍需继续。本研究主要分析与免疫相关的发病机制，并发现 OV 的关键免疫治疗靶点。研究方法利用WGCNA挖掘与OV免疫相关的中枢基因模块和中枢基因。富集分析旨在分析枢纽基因模块的相关通路。利用生物学实验探索中枢基因对 SKOV3 细胞的影响。结果我们发现了两个与 OV 免疫得分相关的中枢基因模块，并发现模块中的这些基因与细胞外基质和病毒感染有关。同时，我们还发现了 6 个与 OV 免疫相关的中枢基因。其中，KIF26B和CREB3L1可通过Wnt/β-catenin通路影响SKOV3细胞的增殖、迁移和侵袭。结论卵巢局部感染或炎症可能会影响卵巢癌的免疫力。KIF26B和CREB3L1有望成为卵巢癌免疫治疗的潜在靶点。

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KIF26B and CREB3L1 Derived from Immunoscore Could Inhibit the Progression of Ovarian Cancer

Background. Ovarian cancer (OV) is characteristic of high incidence rate and fatality rate in the malignant tumors of female reproductive system. Researches on pathogenesis and therapeutic targets for OV need to be continued. This study mainly analyzed the immune-related pathogenesis and discovered the key immunotherapy targets for OV. Methods. WGCNA was used for excavating hub gene modules and hub genes related to the immunity of OV. Enrichment analysis was aimed to analyze the related pathways of hub gene modules. Biological experiments were used for exploring the effect of hub genes on SKOV3 cells. Results. We identified two hub gene modules related to the immunoscore of OV and found that these genes in the modules were related to the extracellular matrix and viral infections. At the same time, we also discovered six hub genes related to the immunity of OV. Among them, KIF26B and CREB3L1 can affect the proliferation, migration, and invasion of SKOV3 cells by the Wnt/β-catenin pathway. Conclusions. The local infection or inflammation of ovarian may affect the immunity of OV. KIF26B and CREB3L1 are expected to be potential targets for the immunotherapy of OV.

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来源期刊

Journal of Immunology Research IMMUNOLOGY-

CiteScore

6.90

自引率

2.40%

发文量

423

审稿时长

15 weeks

期刊介绍： Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.