GEF-H1 的研究进展：生物功能与肿瘤关系

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current molecular pharmacology Pub Date : 2024-02-07 DOI:10.2174/0118761429274883231129103220

Liqi Li, Yunyun Li, Xiaoshu Zhou

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引用次数: 0

摘要

::鸟嘌呤核苷酸交换因子 H1（GEF-H1）是一种由 GDP/GTP 交换调节的独特蛋白质。作为 Rho-GTPase 家族的调控因子，GEF-H1 可通过微管依赖机制和磷酸化调控被激活，从而在多种细胞活动中发挥各种关键的生物功能。这些功能包括调节 Rho-GTPase、细胞骨架形成、细胞屏障、细胞周期、有丝分裂、细胞分化和囊泡贩运。最近的研究揭示了它对肿瘤微环境（TME）成分的重要影响，促进了肿瘤的发生和发展。因此，深入探讨 GEF-H1 的生物学作用及其与肿瘤的关联，有望使其成为治疗肿瘤的重要分子靶点。

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Advancements in the Research of GEF-H1: Biological Functions and Tumor Associations

:: Guanine nucleotide exchange factor H1 (GEF-H1) is a unique protein modulated by the GDP/GTP exchange. As a regulator of the Rho-GTPase family, GEF-H1 can be activated through a microtubule-depended mechanism and phosphorylation regulation, enabling it to perform various pivotal biological functions across multiple cellular activities. These include the regulation of Rho-GTPase, cytoskeleton formation, cellular barrier, cell cycle, mitosis, cell differentiation, and vesicle trafficking. Recent studies have revealed its crucial effect on the tumor microenvironment (TME) components, promoting tumor initiation and progress. Consequently, an in-depth exploration of GEF-H1’s biological roles and association with tumors holds promise for its potential as a valuable molecular target in tumor treatment.

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来源期刊

Current molecular pharmacology Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

4.90

自引率

3.70%

发文量

112

期刊介绍： Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology. Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.