Fatema Al-Rashed, Halemah AlSaeed, Nourah Almansour, Fahd Al- Mulla, Yusuf A. Hannun, Rasheed Ahmad
{"title":"IL-6R（跨信号）是负载脂质的巨噬细胞中胆固醇反向转运的关键调节因子","authors":"Fatema Al-Rashed, Halemah AlSaeed, Nourah Almansour, Fahd Al- Mulla, Yusuf A. Hannun, Rasheed Ahmad","doi":"10.1101/2024.02.07.24302472","DOIUrl":null,"url":null,"abstract":"<strong>Background</strong> Atherosclerosis epitomizes a multifaceted cardiovascular disorder, predominantly characterized by the accumulation of cholesterol-laden plaques within arterial walls. Despite substantial research, the precise mechanisms governing the formation of these cholesterol-rich plaques remain partially elucidated. This study delves into the complex interplay of interleukin-6 (IL-6) receptors, shedding light on their pivotal role in orchestrating cholesterol homeostasis in human macrophages.","PeriodicalId":501527,"journal":{"name":"medRxiv - Allergy and Immunology","volume":"24 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"IL-6R (trans-signaling) is a key regulator of reverse cholesterol transport in lipid-laden macrophages\",\"authors\":\"Fatema Al-Rashed, Halemah AlSaeed, Nourah Almansour, Fahd Al- Mulla, Yusuf A. Hannun, Rasheed Ahmad\",\"doi\":\"10.1101/2024.02.07.24302472\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>Background</strong> Atherosclerosis epitomizes a multifaceted cardiovascular disorder, predominantly characterized by the accumulation of cholesterol-laden plaques within arterial walls. Despite substantial research, the precise mechanisms governing the formation of these cholesterol-rich plaques remain partially elucidated. This study delves into the complex interplay of interleukin-6 (IL-6) receptors, shedding light on their pivotal role in orchestrating cholesterol homeostasis in human macrophages.\",\"PeriodicalId\":501527,\"journal\":{\"name\":\"medRxiv - Allergy and Immunology\",\"volume\":\"24 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Allergy and Immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.02.07.24302472\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Allergy and Immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.02.07.24302472","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
IL-6R (trans-signaling) is a key regulator of reverse cholesterol transport in lipid-laden macrophages
Background Atherosclerosis epitomizes a multifaceted cardiovascular disorder, predominantly characterized by the accumulation of cholesterol-laden plaques within arterial walls. Despite substantial research, the precise mechanisms governing the formation of these cholesterol-rich plaques remain partially elucidated. This study delves into the complex interplay of interleukin-6 (IL-6) receptors, shedding light on their pivotal role in orchestrating cholesterol homeostasis in human macrophages.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
