利用石菖蒲叶提取物绿色合成金纳米粒子并研究其抗老年痴呆潜力

IF 2.5 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Haixia Peng, Shuzhen Zhang, Qiaolian Chai, Zhongchang Hua
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引用次数: 0

摘要

如今,以植物提取物为基础的金纳米粒子(AuNPs)的制备、表征及其抗癌活性已受到广泛关注。石菖蒲是一种典型的中药材,自千年以来一直被用于治疗风湿、哮喘、气管炎等疾病。本研究通过高分辨率透射电子显微镜对反应参数进行了优化,以控制 NPs 的尺寸。通过 X 射线衍射、紫外-可见光谱和傅立叶变换红外光谱等多种表征方法,确认了由石菖蒲叶提取物介导的 AuNPs 制备过程。此外,通过评估胆碱酯酶抑制活性和抗氧化潜力,研究了所制备的 AuNPs 的神经保护潜力。纳米金水提取物表现出最高的抗氧化和抗乙酰胆碱酯酶活性,证实了 AuNPs 可以穿过血脑屏障,提高乙酰胆碱酯酶的水平,同时降低氧化应激水平。研究结果表明,AuNPs 具有抗氧化和抗乙酰胆碱酯酶活性,可用于开发抗氧化应激的抗老年痴呆药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Green synthesis of gold nanoparticles using Acorus calamus leaf extract and study on their anti-alzheimer potential

Green synthesis of gold nanoparticles using Acorus calamus leaf extract and study on their anti-alzheimer potential

Nowadays, the fabrication and characterization of plant extract-based gold nanoparticles (AuNPs) as well as their anticancer activities have gained significant attention. Acorus calamus is a typical Chinese medicinal herb that has been utilized since a period of thousand years for treating rheumatism, asthma, tracheitis, etc. In the current study, the reaction parameters are optimized for managing the size of NPs as categorized by the high-resolution transmission electron microscopy. Various characterization methods such as X-ray diffraction, UV-visible spectroscopy and Fourier-transform infrared spectroscopy were carried out to confirm the fabrication of AuNPs mediated by the leaf extract of A. calamus. Further, the neuroprotective potential of fabricated AuNPs was studied by evaluating the cholinesterase inhibitory activity and antioxidant potential. The nanogold aqueous extracts exhibited the highest antioxidant and anti-acetyl cholinesterase activity, confirming that AuNPs can cross the blood-brain barrier and raise the level of acetyl cholinesterase, at the same time reduces the oxidative stress levels. The obtained results concluded their important potential for development of anti-Alzheimer drug having antioxidant and anticholinesterase activity against oxidative stress.

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来源期刊
Biotechnology and Bioprocess Engineering
Biotechnology and Bioprocess Engineering 工程技术-生物工程与应用微生物
CiteScore
5.00
自引率
12.50%
发文量
79
审稿时长
3 months
期刊介绍: Biotechnology and Bioprocess Engineering is an international bimonthly journal published by the Korean Society for Biotechnology and Bioengineering. BBE is devoted to the advancement in science and technology in the wide area of biotechnology, bioengineering, and (bio)medical engineering. This includes but is not limited to applied molecular and cell biology, engineered biocatalysis and biotransformation, metabolic engineering and systems biology, bioseparation and bioprocess engineering, cell culture technology, environmental and food biotechnology, pharmaceutics and biopharmaceutics, biomaterials engineering, nanobiotechnology, and biosensor and bioelectronics.
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